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The Clinical Research On The Therapy Of "Nourishing Kidney And Strengthening Spleen" Combined With Letrozole To Improve The Height Of Big Bone Age Boys

Posted on:2021-05-24Degree:MasterType:Thesis
Country:ChinaCandidate:X L LiFull Text:PDF
GTID:2404330602980561Subject:Pediatrics of traditional Chinese medicine
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Objective:By comparing changes in children's height,growth rate(GV),bone age standard deviation score(HtSDSBA),bone age and chronological age age ratio(BA/CA),and predicted adult height(PAH),the changes were compared with Recombinant human growth hormone(rhGH)combined with letrozole was compared to evaluate the effect of the therapy of "Nourishing kidney and strengthening spleen" combined with letrozole on the height of older children,and to explore effective treatments to improve the height of such children.New field of medicine in promoting the growth of children.Methods:Sixty large-aged boys who met the inclusion criteria were divided into a treatment group and a control group.The treatment group was treated with Traditional Chinese Medicine orally for tonifying spleen and kidney,and the control group was administered subcutaneous injection of recombinant human growth hormone(AnSu Meng),both groups were given oral letrozole at the same time.The course of treatment is 6 months.Record physical indicators(such as height,weight,staging of sexual development,etc.),auxiliary indicators(such as bone age,liver and kidney function,thyroid function,sex hormones,etc.),TCM syndrome scores,follow-up review of each index after 1 month,3 months,and 6 months of treatment.and calculate the height,GV,HtSDSBA,BA/CA and PAH before and after treatment.The data were analyzed statistically using SPSS 23.0 software to evaluate the effectiveness and safety of the treatment.Results:(1)Comparison of effective indicators:The height,GV,and HtSDSBA of the two groups after treatment were significantly increased compared with those before treatment(P<0.01),and the difference between the treatment group and the control group was not significant(P>0.05),suggesting both the treatments can significantly improved the height of the children.Insulin-like growth factor-1(IGF-1)increased after treatment in the control group compared with that before treatment(P<0.01),but the promotion of IGF-1 in the treatment group was not significant(P>0.05).Although the bone age(BA)of the two groups after treatment was significantly increased compared with that before treatment(P<0.01),the BA/CA was decreased compared with that before(P<0.01),suggesting that both groups of treatment had a significant inhibitory effect on BA.(2)Comparison of TCM Syndrome Points:The total points and individual points of TCM syndromes after treatment in the two groups were significantly reduced compared with those before treatment(P<0.01),and there was no significant difference between the two groups after treatment(P>0.05).The two groups had similar effects in improving children's shape,appetite,complexion,hair,muscle,and stool.(3)Comparison of sex hormones and stages of sexual development:Testosterone(T),luteinizing hormone(LH),and follicle stimulating hormone(FSH)in the two groups were significantly higher than before treatment(P<0.01).Diol(E2)was significantly lower than before treatment(P<0.01).Testicle size after treatment was significantly increased in both groups compared to before treatment(P<0.01),and Tanner stage was also significantly different than before treatment(P<0.01),suggesting that the sexual development process in both groups has progressed.(4)The body mass index(BMI)after treatment was significantly increased in both groups than before treatment(P<0.01),and there was no significant difference in BMI after treatment(P>0.05),suggesting that both groups can effectively increase the BMI of children.There was no significant change in blood pressure between the two groups after treatment compared with before treatment(P>0.05).After treatment in both groups,facial acne increased and the voice became thicker in some children,but there were no other adverse reactions.Follow-up review of blood routine,liver and kidney function,thyroid function,four blood lipids,fasting blood glucose,serum insulin,glycated hemoglobin Both are in the normal reference range,indicating that the safety of the two groups of treatment is generally better.Conclusion:The therapy of "Nourishing kidney and strengthening spleen" combined with letrozole can effectively promote the growth of children,delay the progress of bone age,and thereby improve the PAH of children,and also has significant effects on Spleen and kidney deficiency syndrome.This treatment is generally safer and has no significant adverse effects.
Keywords/Search Tags:large bone age, Yishen Jianpi method, letrozole, height, comparison of Chinese and western medical effects
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