Clinical Observation Of Qingxin Huatan Method In Treating Vascular Cognitive Impairment Of Cerebral Small Vascular Disease With The Phlegm-heat Disturbing Heart Syndrome

Objective: Through the clinical application of the Qingxin Huatan method for the treatment of Vascular cognitive impairment of Cerebral Small Vascular Disease(CSVD-VCI)with the phlegm-heat disturbing heart syndrome,observe the neuropsychological scales MMSE,Mo CA,ADL and SDSVD of patients before and after treatment Changes in points to evaluate the treatment effect;compare the levels of low-density lipoprotein(LDL-C),blood uric acid(UA),and blood homocysteine(hcy)in the serum of patients with CSVD-VCI after treatment with those before treatment Analyze and evaluate the clinical effectiveness and safety of the Qingxin Huatan method on Vascular cognitive impairment of Cerebral Small Vascular Disease with the phlegm-heat disturbing heart syndrome.Methods: The target of this experiment was 72 patients with CSVD-VCI diagnosed in the outpatient department of encephalopathy of Wuhan Traditional Chinese Medicine Hospital and inpatient Western medicine from November 2017 to November 2019(screened according to the relevant diagnostic criteria of this study),randomly divided into observation 36 cases in the group(on the basis of treatment,given Qingxin Huatan recipe),36 cases in the control group(on the basis of treatment with nimodipine oral treatment),after 30 days of treatment,compare the neuropsychology of the two groups before and after treatment Scale MMSE,Mo CA,ADL scores,scores and efficacy of TCM syndromes(SDSVD),and changes in laboratory indicators LDL-C,UA,hcy,statistical analysis of the results of the two groups to verify the treatment of CSVD-VCI on The safety and effectiveness.Results: During observation,2 cases were lost in each of the two groups,and 68 cases were finally observed(34 cases in the observation group and 34 cases in the control group).Pre-treatment observation group,control group,age,gender,education level,related concomitant diseases(such as hypertension,diabetes),neuropsychological scale MMSE score,Mo CA score,ADL score,traditional Chinese medicine syndrome(SDSVD)score and There was no significant difference in efficacy and comparison of laboratory indicators LDL-C,UA,hcy(all P values> 0.05),which are comparable.Before and after treatment,the indexes of the two groups are compared as follows:1 Neuropsychological scale1.1 Compared with before treatment,the MMSE scores of the two groups of patients were improved,and the difference was statistically significant(P <0.01);however,the scores of the observation group and the control group were increased,and there was no significant difference(P> 0.05).1.2 Compared with before treatment,the Mo CA scores of the two groups of patients were improved,and the difference was statistically significant(P <0.01);however,the scores of the observation group and the control group were increased,and there was no significant difference(P> 0.05).1.3 Compared with before treatment,the ADL scores of the two groups of patients were improved,and the difference was statistically significant(P <0.05);however,the scores of the observation group and the control group were increased,and there was no significant difference(P> 0.05).2 TCM syndrome score scale(SDSVD score)and curative effect The SDSVD scores of the two groups were lower than before treatment,and the difference was statistically significant(P<0.01).Compared with the scores after treatment,the score of the observation group was significantly lower than that of the control group(P <0.05).The total effective rate in the observation group was 91.18%,which was better than the control group(82.35%).In the observation group,0 cases were cured,13 cases were markedly effective,18 cases were effective,3 cases were ineffective,and31 cases were effective.In the control group,0 cases were cured,8 cases were markedly effective,20 cases were effective,6 cases were ineffective,and 28 cases were totally effective.3 Laboratory indicators3.1 The LDL-C levels of the two groups were compared.The LDL-C levels in the observation group after treatment were lower than those before treatment(P <0.05),which was statistically significant.There was no significant change in LDL-C levels in the control group(P> 0.05).There was a significant difference in the results of the two groups after treatment(P <0.05).3.2 The UA levels of the two groups were compared.The UA level in the observation group after treatment was lower than that before treatment(P <0.05),which was statistically significant.There was no significant change in UA level in the control group(P> 0.05).There was a significant difference in the results of the two groups after treatment(P <0.05).3.3 Compare the Hcy levels in the two groups.The Hcy level in the observation group after treatment was lower than that before treatment(P <0.05),which was statistically significant.There was no significant change in Hcy level in the control group(P> 0.05).There was a significant difference in the results of the two groups after treatment(P <0.05).Conclusion:1.Qingxin Huatan method can improve the cognitive function of patients with CSVD-VCI,improve their daily living ability,and improve their quality of life.2.Qingxin Huatan method has a clinical effect on improving the symptoms and signs of TCM in phlegm-heat disturbing heart-shaped CSVD-VCI;3.Qingxin Huatan method can reduce the levels of LDL-C,UA,Hcy in the serum of patients with CSVD-VCI;4.Qingxin Huatan method is safe and effective,with little toxic and side effects.