| Purpose To collect the Chinese literature on the clinical application of Mahuang Fuzi Xixin Decoction in the treatment of bradyarrhythmia,and the outcome indicators were the clinical efficacy indicators and drug safety.Through the method of Meta-analysis,statistical research was carried out,so as to provide evidence-based medical evidence for the clinical application of TCM(Traditional Chinese Medicine)in the treatment of bradyarrhythmia.Material and method Due to the different retrieval methods of the major databases,the corresponding retrieval approaches were also different,through the establishment of a complete,in line with the purpose of the study of the inclusion criteria and exclusion criteria.Electronic computer was used to search CNKI,Wanfang,VIP,CBM,Pub Med,Cochrane,while assisting manual search method.Searching literature published in 2010-2019,which was discussed the RCT clinical trial of Mahuang Fuzi Xixin Decoction in the treatment of bradyarrhythmia.According to the inclusion and exclusion criteria of literature,strict screening,data extraction and quality assessment are carried out.The "bias risk assessment tool" of Cochrane was used to evaluate the included literature,and finally through the Review Manager 5.3 software for statistical analysis,the final results were obtained.Results In this study,319 documents were retrieved,and 21 were included after three rounds of screening.According to the statistics of 21 articles,the total number of cases was 1738,including 872 cases in the treatment group(Mahuang Fuzi Xixin Decoction as the main prescription plus or minus treatment or combined with western medicine basic treatment)and 866 cases in the control group(simple western medicine basic treatment).The results of Meta-analysis were as follows:(1)Comparison of clinical efficiency: A total of 21 articles included the clinical effective analysis of the treatment group and the control group.The combined effect amount was RR=1.28(95%CI:1.22,1.34),and the test result was P<0.00001,indicating that the clinical efficiency of the treatment group was higher than that of the control group,and the difference between the two groups was of statistical significance;(2)Comparison of TCM syndrome integral evaluation: A total of 6 articles included the evaluation of TCM syndrome integral.The combined effect amount was MD=-2.99(95%CI:-4.43,-1.54),and the test result was P<0.00001,indicating that the therapeutic effect of the treatment group in improving TCM syndrome integral was higher than that of the control group;(3)Comparison of improving 24-hour average heart rate of patients: A total of 13 articles analyzed the 24-hour average heart rate of patients in the treatment group and the control group.The combined effect amount was MD=5.31(95%CI :6.12,6.51),and the test result P<0.00001,indicating that the treatment group was better than the control group in improving the 24-hour average heart rate;(4)Comparison of improving the 24-hour minimum heart rate of patients: A total of 12 articles analyzed the 24-hour minimum heart rate of patients in the treatment group and the control group.The combined effect amount was MD= 5.50(95%CI:4.30,6.70),and the test result P<0.00001,indicating that the treatment group was better than the control group in impro-ving the patients' 24-hour minimum heart rate;(5)Comparison of shortening the time of clinical symptoms disappearance: A total of 2 articles analyzed the time of clinical symptoms disappearance in the treatment group and the control group.The combined effect amount was MD=-3.21(95%CI:-4.58,-2.13),and the test result P< 0.00001,indicating that the therapeutic effect of the treatment group was better than that of the control group in shortening the time of clinical symptoms disappearance;(6)Comparison of improving improving hemorheology indexes: A total of 3 articles analyzed the hemorheology indexes of the treatment group and the control group,the results of HBV,LBV,FIB,PV indexes showed that P<0.00001,indicating that the therapeutic effect of the treatment group was better than that of the control group in improving hemorheology indexes,and the difference between the two groups was statistically significant.Conclusion The treatment group(Mahuang Fuzi Xixin Decoction as the main prescription)had a significant effect on the total clinical effective rate,improving the TCM syndrome score,improving the 24-hour average heart rate and the slowest heart rate of the patients,shortening the time for the clinical symptoms to disappear,improving the hemorheology index of the patients,and was superior to the control group.According to the side effects mentioned in the included literature,the drug safety of the treatment group was good,which had a certain clinical reference significance in drug safety. |
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