| Objective:1.Study on the application of hyperbaric oxygen combined drug therapy on ACI effect on the serum C-reactive protein,TNF-alpha,IL-8 level,by judging the effect,providing the basis for the exploration of new methods of clinical diagnosis and treatment.2.Study on the application of hyperbaric oxygen combined drug therapy on ACI on the nervous function defect of patients appeared,and evaluate the level of improvement,in order to provide theoretical support for clinical application.MethodsA total of 100 cases of ACI who were hospitalized in Neurology ward two of our hospital from January 1,2016 to June 30,2017,and the criteria for admission are: the time of the disease was controlled between 6h and 72 h,excluded from cerebral hemorrhage with brain CT,diagnosed as ACI,and there was no difference in the risk factors among the patients.The patients enrolled were divided into two groups through the principle of random allocation.The conventional medicine group was used as the regular group(regular group for short),and the hyperbaric oxygen treatment group combined with the conventional drug was used as the hyperbaric oxygen treatment group(hyperbaric oxygen group for short).The specific contents of the two groups are as follows:(1)Regular group: there were 50 cases,including 24 male and 26 female,with an average age of 62.00±10.10.Routinely given:(1)Po Aspirin Enteric-coated Tablets 0.1g QN;(2)Po Hydrogenc clopidogrel sulfate 75 mg QN;(3)Po Atorvastatin 20 mg QN;(4)Tetramethylpyrazine injection 80 mg was added to 250 ml NS for intravenous infusion of QD.(5)Ozagrel injection 80 mg intravenous infusion of QD;(6)Edaravone 30 mg was added to 100 ml NS for intravenous infusion of Q12h;(7)Based on the above drug treatment,according to the patient's condition,proper use of dehydrating agents can reduce intracranial pressure,control blood pressure appropriately,prevent hypoperfusion,regulate blood sugar,correct electrolyte disorder,replenish energy and other symptomatic and supportive treatment.(2)Hyperbaric oxygen group: 50 cases,25 cases of male,female 25 cases,with an average age of 62.28±10.46.Based on the conventional treatment in the control group used hyperbaric oxygen therapy,and the medical oxygen chamber and the model for the domestic GY 32110.Specific process: Use mask method for oxygen inhalation.The oxygen absorption time was 30 minutes,two times in total,and the middle interval was 10 minutes to absorb the air in the cabin.At the end of the two time,after about 25 minutes of decompression at the normal pressure of the cabin,and the frequency of treatment is 1 time a day,and treated for 14 days.(3)Control group: choose the Health examination in our hospital 30 cases,16 cases of male and female 14 cases,with an average age of 60.33±10.31.The regular group and hyperbaric oxygen group draw off fasting venous blood 5ml within 24 hours and after14 days for inspection,and the control group draw off fasting venous blood 5ml.These three groups fasting venous blood were removed after centrifugal blood serum,and storage waiting for inspection.And the inflammatory factors of two groups at different time were recorded: C-reactive protein,TNF-alpha and IL-8.The patient's neurological deficit score(NIHSS)was performed on the day of admission and 14 days after admission to assess the level of clinical rehabilitation and evaluate the effect of the treatment.Results1.There was no significant difference in serum levels of inflammatory factors,Creactive protein,TNF-alpha and IL-8 between regular group and hyperbaric oxygen group before treatment(P>0.05),but the levels of inflammatory factors were significantly higher than those in control group(P <0.05).2.After two treatments for two weeks,the serum inflammatory factors of the hyperbaric oxygen group were lower than those of the regular group,and the difference was significant(P<0.05);3.There was no statistical difference between the two groups in the neurological deficit score(NIHSS)before treatment(P>0.05).After two treatments for two weeks,the score of nerve function defect in hyperbaric oxygen group was lower than that of the regular group,the difference was statistically significant(P<0.05).And through the related calculation,the total effective rate of the hyperbaric oxygen group was significantly higher than that of the conventional drug treatment group.Conclusion1.Routine medical treatment in neurology department can reduce serum inflamem-atory factor levels in patients with ACI,while HPO combined with conventional drug ther-apy can better reduce the level of serum inflammatory factors in patients with ACI,reduce inflammatory injury in brain tissue and protect brain function.2.Routine drug therapy can promote neurological function recovery in patients with ACI,but hyperbaric oxygen combined with conventional drug therapy can better reduce the level of neurological deficit and improve the level of clinical rehabilitation of patients with ACI. |
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