The Study On The Correlation Of Periostin Protein In Traumatic And Non-traumatic Femoral Head Necrosis

Objective Objective to determine whether there is difference in plasma Periostin protein between traumatic and non-traumatic osteonecrosis of femoral head,and to analyze the relationship between Periostin protein content in peripheral blood and osteonecrosis of the femoral head,and to explore its clinical significance.Methods The case samples were collected in March 2016,~2018,March,which were in line with the conditions of the subject.24 cases of traumatic femoral head necrosis,22 cases of patients with steroid induced osteonecrosis of the femoral head patients,22 cases of alcoholic patients with femoral head necrosis and 20 cases of healthy plasma were set for trauma group,hormone group,alcohol group and healthy group,the 4 groups were collected peripheral blood plasma.The plasma Periostin protein concentration in these four groups was measured by enzyme linked immunosorbent assay(ELISA),and there was no significant difference in the difference between the groups.Results This topic through the analysis of the results of experimental study: traumatic femoral head necrosis patients and healthy subjects in plasma Periostin protein was significantly lower than that in patients with steroid induced avascular necrosis of femoral head necrosis and alcoholic patients;the expression of steroid induced femoral head necrosis in patients with Periostin and alcoholic femoral head necrosis in patients with plasma protein but significant differences between the two groups there was no statistical significance(P = 0.057);the expression of Periostin protein in steroid induced osteonecrosis of the femoral head was higher than that in the plasma of patients with traumatic femoral head necrosis patients,with significant difference between two groups(P=0.003);the expression of Periostin protein in steroid induced osteonecrosis of the femoral head in the plasma of patients was higher than that in healthy controls,the two groups have statistical significance the difference(P=0.002);the expression of Periostin protein in alcohol induced osteonecrosis of the femoral head was higher than that in the plasma of patients with trauma Osteonecrosis of the femoral head patients,with significant difference between two groups(P<0.001);the expression of Periostin protein in patients with aionfh in plasma was higher than that in healthy controls,with a statistically significant difference between the two groups(P<0.001);traumatic avascular necrosis of the femoral head patients and healthy subjects in plasma the expression of Periostin protein was lower and the difference between the two groups was not statistically significant(P = 0.770);Periostin group of traumatic femoral head necrosis of plasma protein content than non traumatic femoral head necrosis group,with significant difference between two groups(P<0.001);the content of Periostin protein in non traumatic femoral head necrosis group than in plasma health group,with significant difference between two groups(P<0.001)Conclusions The plasma levels of Periostin protein in patients with steroid necrosis of the femoral head and patients with alcoholic femoral head were higher than those in healthy persons and patients with traumatic avascular necrosis of the femoral head.The plasma levels of Periostin protein in the patients with non traumatic avascular necrosis of the femoral head were significantly higher than those of the patients with traumatic femoral head necrosis.It is suggested that Periostin protein in plasma may be a biological indicator of nontraumatic necrosis of the femoral head.In addition,this study suggests that large doses of clinical hormones and long-term alcoholism may stimulate the body to produce Periostin protein,which may lead to steroid and alcoholic necrosis of the femoral head.