The Clinical Significance Of Dynamicly Detecting Feacal Calprotectin In Premature Infants With Feeding Intolerance And Necrotizing Entoroclitis

ObjectiveThrough dynamicaly monitoring fecal calprotectin level in different periods of premature,to find the clinical significance in preterm infants with necrotizing enterocolitis,and to help to differentiate and give treatment.MethodChoose the preterm infant suited for criteria from December in 2015 to February in 2017,admitted in affiliated hospital of Taishan Medical University.Combined with clinical manifestation,laboratory examination,imaging examination,etc.,and according to the feeding intolerance diagnostic criteria and revised standard of BELL stage(chart 1),the subjects is divided into:(1)necrotizing enterocolitis group(2)feeding intolerance but no necrotizing enterocolitis(3)feeding tolerance group.Using Enzyme-Linked immunosorbent Assay(ELISA)processing.Data is analysed by SPSS 17.0 statistical software.Results1.FT group cases: 38 cases,FI: 32 cases,necrotizing enterocolitis :13 cases.NEC period I : 13 cases.Gestational age,birth weight,and sex ratio had no statistical difference(P > 0.05).GA are(31.08±1.8)w,(31.2±1.4)w,(31.4±2.1)w respectively,(P=0.702),BW are(1482.7±438.8)g,(1518.7±503.6)g and(1418.3±492.6)g respectively,(P= 0.433),the ratio of 21/17 17/15 and 9/12 respectively,(P = 0.257).2.FC testing results: 1.The feeding tolerance group(day 7 readings: day 3 readings)average readings:(day 14 readings: day 7 readings)average readings =1.06±0.08: 1.02± 0.12,there was no statistical significance difference(P>0.05).2.The feeding intolerance groups: feeding tolerance period average readings :(feeding intolerance period values: feeding tolerance period values)average =1.08±0.12:1.42±0.05,(P<0.05),and difference have statistical significance.3.Necrotizing enterocolitis stage I groups:(1)feeding tolerance group average:(feeding intolerance readings: feeding tolerance values)mean=1.05±0.08: 1.62±0.06.(2)(feeding intolerance readings values: feeding intolerance readings values mean):(necrotizing enterocolitis values: feeding intolerance values mean)=1.00±0.0: 2.14±0.18,(P<0.05),and difference have statistical significance.Conclusion1.Selected appropriate for gestational age infant from 28 weeks to 32 weeks,for neonatal feeding tolerance and feeding intolerance or necrotizing enterocolitis,their Gestational age,birth weight and gender has no obvious difference.2.The intestinal function is stable with feeding tolerance,and monitore FC value change has no obvious difference.Intestinal function changes such as FI group(feeding intolerance)and NEC group(phase?),monitoring FC value increase gradually,which showed that a bowel dysfunction lead FC levels to increase.3.FC value is dynamic changes in bowel symptoms evolution,and is a kind of safe and convinent indicators.Dynamicly monitore FC for feeding intolerance and early indentification and diagnosis of NEC is of great significance.