Analysis Of The Relationship Between The Bone Mineral Density And Blood Lipid,Blood Pressure Etc. In Male Patients With Type 2 Diabetes Mellitus

Objective:By analyzing the relationship between the bone mineral density and blood lipid and blood pressure etc.of male type 2 diabetes patients,to forecast the risk factors for occurrence of osteoporosis in male patients with type 2 diabetes mellitus,and to provide more theoretical basis and valuable references for early prevention and treatment of osteoporosis of type 2 diabetes patients.Methods:135 male patients with type 2 diabetes mellitus who were admitted to the second ward of Endocrinology Department of Shandong Provincial Hospital from 2016 to 2017 and had fairly complete medical laboratory tests data f'or blood lipid indicators and Dual-energy X-ray bone density measurement were recruited.All the patients were selected into the normal bone quantity group(Group A,47 patients),the low bone quantity group(Group B,55 patients)and the osteoporosis group(Group C,33 patients)as per the bone density of non-dominant distal forearm.Variance analysis(normally distributed data)and rank sum test(non-normally distributed data)were used to compare the difference in blood lipid and blood pressure among the three groups.After adjustment for age,Pearson correlation analysis(normally distributed data)and Spearman correlation analysis(non-normally distributed data)were used to analyze the simple correlation between blood lipid,blood pressure and bone mineral density,and after age correction,the partial correlation between blood lipid,blood pressure and bone mineral density was analyzed.Multinomial logistic regression models were adopted to estimate odds ratios(OR)of each index for the occurrence of osteoporosis and its 95%confidence interval(95%CI)by adjusting the confounding factor of age.Chi-square tests were used to analyze the relationship between hypertension and osteoporosis in 135 male patients with type 2 diabetes mellitus.Results:The differences in total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),apolipoprotein B(APOB),apolipoprotein A/B(APO-A/B),and systolic blood pressure(SBP)are statistically significant(P<0.05).Simple correlation analysis showed that TC,LDL-C,APOB and SBP were negatively correlated with bone mineral density(P<0.05),and APO-A/B was positively correlated with bone mineral density(P<0.01).After adjustment for age,partial correlation analysis showed that TC,LDL-C,APOB,SBP and diastolic blood pressure(DBP)were negatively correlated with bone mineral density(P<0.05),and APO-A/B was positively correlated with bone mineral density(P<0.01).The adjusted OR(95%CI)of TC,LDL-C,APOB,SBP and DBP for the risk of osteoporosis are 1.65(1.16-2.24),1.75(1.15-2.65),7.04(1.88-26.46),1.02(1.01-1.04)and 1.03(1.01-1.06),respectively.The adjusted OR(95%CI)of APO-A/B is 0.23(0.09-0.2 1).No correlation was found between the diagnosis of hypertension and the occurrence of osteoporosis in 135 male patients with type 2 diabetes mellitus.Conclusion:For male patients with type 2 diabetes mellitus,who have high levels of total cholesterol,low density lipoprotein cholesterol.apolipoprotein B and poor blood pressure control have higher risk of occurrence of osteoporosis.For male patients with type 2 diabetes mellitus,close monitoring of the above indicators,active lipid lowering and blood pressure controlling are of great significance in preventing and treating osteoporosis in male patients with type 2 diabetes mellitus.