Predictive Value Of Platelet To Lymphocyte Rate On Contrast-induced Acute Kidney Injury In Patients Who Underwent Primary Percutaneous Coronary Intervention

Objectives: To investigate the value of platelet to lymphocyte ratio(PLR)in predicting Contrast induced acute kidney injury(CI-AKI)in patients with acute myocardial infarction underwent primary percutaneous coronary intervention(PPCI).Methods: 437 patients who underwent PPCI in our hospital from January 2014 to June 2019 were enrolled.Baseline data,interventional data and laboratory findings were recorded.The serum creatinine level was measured at the time of 24h?48h and 72 h postprocedure was discharged.Patients were divided into control group and the CI-AKI group according to a ?25% increase in serum creatinine within 48-72 hours post-PCI.The differences in characteristics,such as PLR,between the control group and the CI-AKI group were compared,Logistic analysis was used to identify the risk factors of CI-AKI.Receiver operating characteristic curve was drawn to determine the predictive accuracy of the PLR.Results: CI-AKI occurred in 91 of the 437 patients,with an incidence of 20.8%.Patients in the CI-AKI group had significantly higher PLR than those in the control group(146.21±78.92 VS 183.08±108.73;p<0.05).In multivariate logistic regression analysis,PLR was an independent predictors of CI-AKI [OR(95%CI):1.004(1.001-1.007),p=0.004].For development of CI-AKI after primary PCI,the PLR had an area under the curve(AUC)value of 0.618(95%CI: 0.571-0.664,p=0.001)on the ROC curve.For a cutoff value of 140.9,the PLR had a 63.7% sensitivity,56.9% specificity,for predicting CI-AKI.Conclusion: The PLR was an independent predictor of CI-AKI in patients with primary percutaneous coronary intervention.