| Objective This study aim to analyze the correlation between serum caveolin-1(cav-1)and C-reactive protein(CRP)levels and clinical phenotype and prognosis in patients with acute coronary syndrome.Methods1.A total of 254 patients who underwent coronary angiography in our hospital for chest pain were selected.According to clinical manifestations,laboratory tests and coronary angiography results,they were divided into 213 cases of acute coronary syndrome(ACS)group(176 cases in unstable angina pectoris(UAP)group,37 cases in myocardial infarction(AMI)group)and coronary arteries.41 patients with negative angiography control group;2.To collect general clinical data,biochemical indicators and coronary artery disease status of patients;regular telephone or outpatient follow-up visits to record the incidence of major cardiovascular adverse events(MACE events)within 1 year after discharge;3.Enzyme-linked immunosorbent assay(ELISA)was used to detect serum caveolin-1 level,and an automatic biochemical analyzer was used to detect serum C-reactive protein level;4.SPSS 21.0 was used for independent sample T test of measurement data.Chi-square test was used for counting data.ANOVA analysis was used for comparison among multiple groups.Pearson test was used for correlation of continuous variables.The relationship between CAV-1,CRP and MACE was analyzed by binary logistic regression.Draw the receiver operating characteristic(ROC)curve to define the best cut-off value.Results1.Among the 254 subjects,133 were male and 121 were female,with an average age of(60.03 ± 10.05)years.The serum CAV-1 level of the patients in the ACS group was not statistically different from that in the control group(194.77±17.00 pg/m L VS190.39 ± 18.23 pg/m L,P>0.05);CAV-1 in AMI group was higher than the control group(202.49 ± 18.18 p /m L VS 190.39 ± 18.23 pg/m L,P<0.05)and UAP group(202.49 ± 18.18 p /m L VS 193.14 ± 16.34 pg / m L,P<0.05);there was no significant difference between the UAP group and the control group(193.14 ± 16.34 pg/m L VS190.39 ± 18.23 pg/m L,P>0.05)2.There was no difference in serum CRP levels between the ACS group and the control group(3.81 ± 4.71 mg/L VS 3.57 ± 3.84 mg/L,P>0.05);the plasma CRP level in the AMI group was higher than that in the UAP group(7.73 ± 6.48 mg / L VS2.99 ± 3.79 mg/L,P<0.05)and the control group(7.73 ± 6.48 mg/L VS 3.57 ± 3.84 mg / L,P<0.05);there was no significant difference between the UAP group and the control group(2.99 ± 3.79 mg / L VS 3.57 ± 3.84 mg / L,P>0.05);3.One-way analysis of variance showed that serum cav-1 and CRP levels had no significant correlation with lesion count and TIMI score(P > 0.05).Pearson linear correlation analysis results showed that serum cav-1 was positively correlated with CRP,and serum CRP was positively correlated with TC and LDL(P<0.05).4.Statistics of MACE events within 1 year of ACS patients,including MACE event positive group(27 persons),MACE event negative group(186 persons),MACE event positive group serum CAV-1 level was higher than MACE event negative group(205.29 ± 17.90 pg/m L VS 193.11 ± 16.30 pg/m L,P<0.05);CRP levels in the MACE event positive group were higher than those in the MACE event negative group(6.51± 6.36 mg/L VS 3.39 ± 4.26 mg/L,(P<0.05)5.Binary Logistic analysis found that cav-1 and CRP were independent risk factors for MACE events in patients with ACS(P<0.05).According to the statistical results of MACE events,the receiver operating curve(ROC)showed that the area under the ROC curve of cav-1 was 0.677(0.562-0.783),and the optimal cut-off value was 191.33 pg/m L,with a sensitivity of 81.48 % and specificity of 49.46 %.The area under the ROC curve of CRP was 0.650(0.535-0.765),and the optimal cut-off value was 3.55mg/L.At this time,the sensitivity was 55.56% and the specificity was70.43 %.The combined prediction of cav-1 and CRP was 0.688(0.577-0.800),the optimal cut-off value was 0.824,the sensitivity was 86.56 %,and the specificity was48.15%.Conclusion1.Serum CAV-1 and CRP are related to the incidence of AMI.However,these two indicators are not associated with UAP,the number of lesions,as well as the TIMI score.2.There is a positive linear correlation between serum CRP levels,CAV-1,TC and LDL.3.Both elevated serum CAV-1 and CRP levels are independent risk factors for cardiovascular adverse events in ACS patients.It is of predictive value to monitoring the levels of serum CAV-1 and CRP of ACS patients. |
