Comparison Of Two Criteria For Diagnosis Of Bronchopulmonary Dysplasia In Premature Infants In Predicting Long-term Poor Prognosis

Objective: Compare the difference between traditional diagnostic criteria and correct age 40 week criteria for diagnosis of BPD to predict clinical prognosis.Methods: This retrospective study collected the hospitalization and follow-up data of the VLBW and ELBW infants discharged from Hunan children's Hospital.Analyze the occurrence of long-term poor prognosis in children with BPD and compare the difference between traditional diagnostic criteria and correct age 40 week criteria for diagnosis of BPD to predict clinical prognosis.Results:1)A total of 144 children were included in the study,and 100(69.6%)children with BPD were diagnosed according to traditional criteria.36(25%)cases of BPD diagnosed according to the 40 weeks of corrected age diagnostic criteria.2)At 18 months corrected age,there were 13cases(9%)with poor growthand development prognosis,36 cases(25%)with poor neurodevelopmental outcome,and 42 cases(29.1%)with composite poor outcome(have any one of the respiratory or neurodevelopmental outcome).3)There were 13 cases of poor growth prognosis in preschool age,20 cases of poor respiratory system prognosis,10 cases of neurodevelopmental poor prognosis,and 28 cases(22.7%)of composite poor prognosis(any one of the poor growth,respiratory and neurodevelopmental prognosis).4)Through logistic regression analysis and the area under the ROC curve,the traditional standard diagnosis of BPD and the correct age 40 weeks standard diagnosis of BPD have similar prediction accuracy for the neurological and comprehensive poor prognosis of children at 18 months of correction.Correct age 40 weeks standard diagnosis of BPD is better than the traditional diagnostic criteria for predicting the prognosis of dysplasia at 18 months of age.5)Traditional criteria for diagnosis of BPD are associated with pre-school comprehensive poor prognosis(p=0.025).Correct age 40 weeks diagnosis of BPD is significantly associated with pre-school growth and development,respiratory system,and neurological poor prognosis(p<0.05).6)Correct age 40 weeks standard diagnosis of BPD has better predictive accuracy than the traditional standard in predicting preschool poor neurological,poor respiratory,poor growth and development,and composite poor prognosis.Conclusion:1)Correction of the 40-year-old standard diagnosis of BPD is better than traditional diagnostic criteria for predicting the prognosis of 18-month-old dysplasia.2)Correct age 40 weeks standard diagnosis of BPD,the prediction accuracy of the preschool neurodevelopmental,respiratory system,growth and composite poor prognosis are better than traditional diagnostic standards.