A Clinical Research On Prescription Of Soothing Liver And Invigorating Spleen To Interfere In The Syndrome Of Liver Qi Depression And Spleen Dificiency In Type2Diabetes Mellitus And Non-alcoholic Fatty Liver Disease

Purpose:To discuss the understanding of traditional Chinese medicine about type2diabetes mellitus and non-alcoholic fatty liverdisease by using prescription of soothing liver and invigorating spleen. To observe the therapeutic efficacy of this method in treating the syndrome of liver qi depression and spleen dificiency in type2diabetes mellitus and non-alcoholic fatty liverdisease.Methods:A randomized, controlled trial was conducted.60patients with the syndrome of liver qi depression and spleen deficiency in type2diabetes mellitus and non-alcoholic fatty liverdisease were randomly classified into two proups. Besides the basic of regular treatment and modern medicine,the patients of treated group (n=30) were treated by Chinese medicine while the patients of controlled groups (n=30) were not. Twelve weeks was a course of treatment. The observed indexes included both curative effect indexes, such as clinical symptoms, FBG, P2HBG, HbAlc, AST, ALT, TC, TG, HDL-C, LDL-C, HOMA-IR, liver type-B ultrasonic, and safety indexes, such as routine blood, urine and stool test,, the function of liver and kidney and harmful reaction. All data were analyzed by the SPSS17.0statistics software.Results:Prior treatment, no differences were found in the gender, age, course of disease between the two groups.①The total effective rate of treated group’s patients was86.7%, while the controlled group was60%. The treated group gained an advantage over the controlled group (P<0.01).②he fasting blood glucose, postprandial blood glucose of two groups were lowered(.P<0.01). And the treated group had an advantage than the controlled group(P<0.05). The HbAlc of two groups were lowered(P<0.01). And the treated group had an advantage than the controlled group(P<0.01).③ompared with pre-treatment, in two group patients’TG、TC、 LDL-C had a lowering(P<0.01), and HDL-C had marked increased(P<0.01). And the treated group had an advantage than the controlled group(P<0.01). That showes that the combination of western medicine and chinese medicine has the function of adjusting fat and it does much better than using western medicine effected in TG, TC, LDL-C and HDL-C.④he AST and ALT of two groups were lowered(P<0.01).And the treated group had an advantage than the controlled group(P<0.01).⑤ll of patients after treatment of FINS and HOMA-IR decreased significantly compared with before treatment, there were significant differences(P<0.01). And the treated grouppatients’FINS had an advantage than the controlled group(P<0.01),while HOMA-IR had an advantage than the controlled group(P<0.05).⑥The treatment group patients’liver B-mode ultrasonography had improved(p<0.05), while the control group showed no significant difference before and after treatment (P>0.05).⑦t the same time, Group therapy for patients with renal function tests were within the normal range.Conclusion:Chinese medicine of method in soothing liver and invigorating spleen has a sure curative effected in treating type2diabetes mellitus and non-alcoholic fatty liver disease. It is worth studying deeply and developing further.