Analysis Of The Relationship Between Intestinal Microorganisms And Acute Myocardial Infarction

Objective:The incidence of acute myocardial infarction(AMI)is increasing year by year and has become a serious threat to human healthbecause of aging populations.The study have shown that gut microbiota are associated with a wide variety of human diseases,including type 2 diabetes mellitus and autism.Therefore,the study aimed to investigate the characteristics of gut microbiota in patients with AMI.Methods:A total of 20 patients with AMI and 20 healthy controls from the same family or neighbors with similar living habits were included in this study.We collected 60 stool and 60 blood samples.The differences in the fecal microbiota community were analyzed via 16 ribosomal RNA-sequencing.Furthermore,the levels of trimethylamine N-oxide(TMAO)and short-chain fatty acids(SCFA)in the blood were detected using ELISA.Results:The study found that the intestinal flora structure of patients with AMI was significantly different from that of the healthy control group.However,the intestinal flora diversity did not change significantly.Bacteroidetes and Verrucomicobia showed an upward trend,while Proteobacteria showed a downward trend in AMI patients.During a longitudinal study to compare the changes in bacteria before and after treatment,we found that routine cardiac admission therapy one week after percutaneous coronary intervention(PCI)surgery had no effect on the microbiol community structure in patients.There were significantly higher levels of plasma TMAO,a metabolite of bacterial flora,in AMI patients' than in the control group.In contrast,there was no obvious change in SCFA.Conclusion: The intestinal flora structure of AMI patients was different from that of healthy controls,and TMAO in serum of AMI patients was elevated.