| Objective Cerebrovascular disease with high incidence,morbidity and high mortality,cerebral infarction is the most common cerebrovascular disease.Before the onset of cerebral infarction there is generally a long-term chronic cerebral blood shortage and timely intervention of chronic cerebral insufficiency is of great significance to reduce the occurrence of cerebral infarction.The modified framingham stroke scale can assess the risk of stroke in different genders over a10-year period.The purpose of this study was to compare chronic cerebral blood deficit patients with low and high risk of stroke for 10 years,to analyze the difference of TCM syndrome distribution in patients with chronic cerebral blood shortage with different risk of disease,to provide evidence for TCM prevention and treatment of stroke.Methods This study is based on the special subject of business construction of the national TCM clinical research base of the state administration of traditional Chinese medicine”Study on screening of risk factors and TCM syndromes in patients with symptomatic cerebral perfusion artery stenosis”.90 patients with chronic cerebral blood shortage who were hospitalized in Hubei hospital of traditional Chinese medicine were selected to assess the risk of stroke of each patient using the modified framingham stroke scale.According to the score,the patients were divided into three groups: low risk,medium risk and high risk.General information,Previous history,personal history,vital signs,signs and symptoms,information of the four diagnosis of traditional Chinese medicine,biochemical examination,color doppler ultrasound of neck blood vessels,TCD,head and neck imaging examination,modified framingham scale were recorded on the day the subjects were enrolled,and input the data into the EXCEL sheet specially designed by the study group.Spss21.0 statistical software was used for statistical analysis.The measurement data in this study were tested for normality and homogeneity of variance,and the appropriate statistical method was selected according to the test results.For the comparison of frequency distribution differences among multiple groups of samples,the chi-square test was used for data conforming to chi-square distribution,while Fisher's exact probability method was used for data not conforming to chi-square distribution.All statistical tests were conducted by bilateral test,and the difference was statistically significant when P < 0.05.On the basis of data analysis,combined with the analysis of professional knowledge,the results are obtained and discussed reasonably.Results 1.Among the interdictable risk factors of patients with chronic cerebral circulation insufficiency,the three with the highest frequency were hypertension,hyperlipidemia and diabetes,followed by less physical exercise,high homocysteine,smoking,obesity,and the lowest frequency of cardiovascular disease and atrial fibrillation.2.Patients with chronic cerebral circulation insufficiency disease syndrome factor mainly distributed in the brain,followed by kidney and spleen,liver and heart are the least.The deficiency syndromes of the disease are mainly marrow deficiency,qi deficiency and blood deficiency,and phlegm turbidity is the main positive evidence.3.There were statistically significant differences in the distribution of disease syndromes among the three groups(P <0.05).The low-risk group was dominated by qi deficiency and blood deficiency,the medium-risk group was dominated by marrow deficiency,qi deficiency,blood deficiency and phlegm turbidity,and the high-risk group was dominated by marrow deficiency and phlegm turbidity.Some of the patients also contain wind,blood stasis,Yang excess and other solid syndromes.4.There were statistically significant differences in the distribution of marrow deficiency and phlegm turbidity among the three groups(P < 0.05).The distribution of other syndromes was no significant differences.Conclusion 1.The interdictable risk factors of chronic cerebral circulation insufficiency distribution is given priority to with hypertension,hyperlipidemia,diabetes,followed by physical exercise less,hyperhomocysteinemia,smoking,obesity,cardiovascular disease,atrial fibrillation.The frequencies of all risk factors in high-risk group are higher than medium-risk group and low-risk group.2.The overall syndrome factor distribution deficiency syndrome of chronic cerebral circulation insufficiency than empirical,deficiency syndrome is given priority to with marrow deficiency,qi deficiency,blood deficiency;The empirical is given priority to with phlegm,blood stasis,hand,wind syndrome factor.This shows that the etiology and pathogenesis of TCM of chronic cerebral circulation insufficiency is given priority to virtual,and combines phlegm,wind,blood stasis,Yang excess.3.Low risk group of patients syndrome factor distribution is given priority to with qi deficiency,blood deficiency.Syndrome factor distribution of the patients in the medium-risk group with marrow deficiency,qi deficiency,blood deficiency,phlegm turbidity distribution are the same.Element distribution of high-risk group of patients is given priority to marrow deficiency and phlegm,some patients clip to the wind,blood stasis,Yang excess.It indicated that with the increase of the risk of stroke,the TCM syndromes of CCCI patients gradually changed from deficiency to deficiency-positive mixing.4.Marrow deficiency and phlegm turbidity were significantly different in the three groups of CCCI patients,and increased gradually from the low-risk group to the high-risk group,indicating that the two syndromes of marrow deficiency and phlegm turbidity may be positively correlated with the risk of stroke.5.In the process of preventing and treating of CCCI,in addition to the active prevention and controlling for interventional risk factors such as hypertension,diabetes,hyperlipidemia,hyperhomocysteinemia,smoking,lack of exercise,etc.The patients with marrow deficiency and phlegm turbidity should also be paid attention to and actively intervened in TCM to reduce the risk of stroke. |
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