The Study On Related Factors And TCM Syndrome Distribution Of Cancer Related Fatigue In Lung Cancer Patients

Purpose Through clinical analysis to explore the related factors of cancer-related fatigue(CRF)in lung cancer patients,and analyze the distribution of different documents in different degree of CRF patients,to provide reference experience for clinical treatment of cancer related fatigue.Methods To select patients with lung cancer from June 2018 to January2019 in the Department of Oncology of the integrated Chinese and Western Medicine Hospital of Wuhan,we used Piper Fatigue scale(PFS)to screen out the patients with CRF and improved the general condition questionnaire in detail,under the guidance of experts in Traditional Chinese medicine(TCM)Syndrome diagnosis.The data collected were analyzed with SPSS 24.0 statistical software.Results Of the 186 patients,72 cases were mild fatigue,94 cases were moderate fatigue and 20 cases were severe fatigue.PFS's overall score was 3.2710±2.055,indicating that lung cancer patients with CRF were generally moderately fatigued.The results of single factor ANOVA analysis showed that there were significant differences in PFS scores among the patients with CRF(P<0.05).The symptoms of mild fatigue were marked by emotional fatigue,moderate fatigue by behavioral fatigue and cognitive fatigue,and severe fatigue by cognitive fatigue and emotional fatigue.Statistical analysis suggests that 186 cases of lung cancer in CRF were not related to sex,age,family history of cancer,pathological type,distribution,Degree of differentiation,Surgical treatment,radiotherapy status and targeted therapy status(P>0.05),While related to education level,mode of payment,employment status,the score of KPS,duration of illness,Primary tumor size,clinical stage,The State of chemothe-rapy,whether had the treatment of TCM(P<0.05),the score of KPS was an independent factor of CRF in lung cancer patients(P <0.05).According to the statistics of TCM documents,the proportion of CRF lung cancer patient's documents from high to low was Spleen-qi deficiency syndrome,lung-qi deficiency syndrome,phlegm-dam pness deficiency syndrome,blood deficiency syndrome,stagnation of liver-qi,blood stasis syndrome,heat-toxind syndrome,kidneyyince deficiency syndrome,kidney-yang deficiency syndrome.The distribution of TCM documents of patients with different fatigue degree was different in spleen-qi deficiency syndrome,phlegm-damp syndrome,stagnation of liver-qi,blood stasis syndrome,heat-toxin syndrome,kidney-yince deficiency syndrome,kidney-yang deficiency syndrome(P<0.05),there was no significant difference in the TCM distribution of lung-qi deficiency syndrome and blood deficiency syndrome(P>0.05).There were 58 cases of combined syndromes in CRF,among which combination of four types of syndromes were the most common,were 22 cases(37.93%),combination of three types of syndromes were 18 cases(31.03%),combination of five types of syndromes syndromes were 12 cases(20.69%),combination of two types of syndromes were 6 cases(10.34%).In the distribution of cancer-related fatigue TCM syndrome,Deficiency syndromes run through the whole course of the disease.With the development of the disease,the syndrome tends to be be complicated due to deficiency leading to excess and the accumulation of multiple viscera in one viscera.Mild fatigue is mainly based on the syndromes of deficiency syndromes.A few patients can also have stagnation of liver-qi,and phlegm-damp,and patients with moderate fatigue can involve multiple organs(lung-qi,spleen-qi),and empirical symptoms such as phlegm-damp and heat-Toxic syndromes and other.syndromes are more significant than patients with mild fatigue,patients with severe fatigue have more severe syndromes(lung-qi,spleen-qi,kidney-qi)and empirical syndromes,especially liver-stagnation syndrome and blood stasis syndrome.Conclusion The degree of cancer-related fatigue in lung cancer patients is correlated with the degree of education,the mode of payment,the status of employment,the score of KPS,time of illness,clinical stage of tumor,whether chemotherapy or TCM treatment.The score of KPS was the main influencing factor,negatively correlated with fatigue.among the TCM syndrome distribution of CRF in lung cancer patients,deficiency syndrome runs through the whole course of the disease.With the degree of fatigue getting worse,the symptoms of positive syndrome become more prominent,early diagnosis and intervention should be made to relieve the patients' pain and improve the quality of life.