| Objective1.Analyze the clinical characteristics of non-motor symptoms such as pain,sleep quality,anxiety and depression,cognitive function and olfactory-recognition function in patients with spastic torticollis;2.Analyze the characteristics of TCM syndromes in patients with spasmodic torticollis and their correlation with non-motor symptoms such as pain,sleep quality,anxiety and depression,cognitive function and olfactory-recognition function.Methods:Selection in February 2018 to December 2019 in Anhui University of Traditional Chinese Medicine Institute of Neurology Hospital outpatient and hospitalization in 36 patients with diagnostic criteria of idiopathic spasmodic torticollis group set as spasmodic torticollis(ST group),select hospital or outpatient patients' families in healthy people,43 cases of healthy control group(control group),(1)application of Toronto Western Spasmodic Torticollis Rating Scale(TWSTRS)assessment ST group is associated with disease;Using Numerical Rating Scale(NRS),Pittsburgh Sleep Quality Index(PSQI),Hamilton Anxiety scale(HAMA)and Hamilton Depression scale(HAMD),Montreal Cognitive Assessment scale(Mo CA),the Chinese Smell Identification Test-16(CSIT-16)for ST group and control group respectively for pain,sleep quality,anxiety,depression,cognitive function,the olfactory function for evaluation.The differences between the ST group and the control group in pain,sleep quality,anxiety and depression symptoms,cognitive function and smell function were analyzed,and the clinical characteristics of non-motor symptoms and their correlation with gender,age,course of disease,TWSTRS total score and three subscales were analyzed.(2)Analyze the TCM syndromes of patients with spastic torticollis and their correlation with non-motor symptoms such as pain,sleep quality,anxiety and depression,cognitive function and olfactory-recognition function.Results:1.There were significant differences in pain,sleep quality,anxiety,depression and cognitive function between the ST group and the control group(p<0.01);There was no statistically significant difference in olfaction recognition function between the two groups(p>0.05).2.(1)There was no significant correlation between pain and gender,age,course of disease,TWSTRS severity of torticollis and degree of disability(p>0.05).Pain was positively correlated with TWSTRS total score and pain score(r=0.459,p=0.000<0.01;r=0.031,p=0.033 <0.05).(2)There was no significant correlation between the sleep quality and PSQI factors of ST patients and the scores of age,gender,course of disease,TWSTRS total score,severity of torticollis,degree of disability and pain(p>0.05).(3)Anxiety scores of ST patients were not significantly correlated with age,gender,course of disease,TWSTRS-severity of torticollis and degree of disability sub-scale scores(p>0.05),but were positively correlated with TWSTRS total score and pain sub-scale scores(r=0.459,p=0.000<0.01).r=0.031,p =0.033<0.05).HAMA factor had no significant correlation with age,gender,course of disease,TWSTRS total score,severity of torticollis,degree of disability,and pain score(p>0.05).(4)There was no significant correlation between depression scores of ST group patients and age,gender,course of disease,TWSTRS total score,severity of torticollis,and pain subscale scores(p>0.05).There was a positive correlation with TWSTRS-degree of disability score(r=0.406,p=0.042<0.05).All the factors included in HAMD scale were not significantly correlated with age,gender,course of disease,TWSTRS total score,severity of torticollis,degree of disability,and pain scores of the three sub-scales(p>0.05). (5)There was no significant correlation between the cognitive function score of ST group patients and the scores of gender,course of disease,TWSTRS total score,severity of torticollis,degree of disability and pain(p>0.05).There was a negative correlation with age(r=0.144,p =0.008 <0.01).The factor visual space and executive ability of Mo CA were negatively correlated with age(r=-0.078,p=0.000<0.01),TWSTRSseverity of torticollis(r=-0.253,p=0.008<0.01),and TWSTRS total score(r=0.208,p=0.022<0.05).Note the negative correlation with gender(r=0.373,p=0.025<0.05).(6)There was a positive correlation between olfaction function and age in the ST group(r=0.028,p=0.008<0.01),But there was no significant correlation with gender,course of disease,TWSTRS total score,severity of torticollis,degree of disability,and pain score of the three sub-scales(p>0.05).3.(1)There was significant correlation between TCM syndrome type and gender distribution in ST group(x2 =36.0,p=0.000<0.01);There was no significant correlation with age,course of disease,TWSTRS total score,severity of torticollis,degree of disability,and pain scores in the three sub-scales(p>0.05).(2)There was no significant correlation between the TCM syndromes of ST and pain,anxiety,depression,sleep quality,cognitive function,and smell function(p>0.05).Conclusion:1.Patients with spastic torticollis have pain,sleep disturbance,anxiety,depression,cognitive impairment and other non-motor symptoms.2.The pain,sleep quality,anxiety and depression symptoms of patients with spasmodic torticola were not correlated with age,sex or course of disease;Cognitive function and olfactory function have nothing to do with gender and disease course.Cognitive function is negatively correlated with age,while olfactory function is positively correlated with age.Sleep quality,cognitive function and olfactory function were not associated with motor symptoms.There was a positive correlation between pain and disease severity.Anxiety symptoms were positively correlated with pain score and disease severity.Depressive symptoms were positively correlated with the degree of disability.3.The TCM syndrome type of patients with spastic torticollis is related to gender;There was no significant correlation with age,course of disease and motor symptoms.No significant correlation was found with pain,anxiety,depression,sleep quality,cognitive function,olfactory-like function. |
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