| Objective: Study on the risk factors of chronic total coronary artery occlusion and its influence on left ventricular function.Methods:From July 2016 to September 2018 in the Department of Cardiology of the people's Hospital of Xinjiang Uygur Autonomous region,190 patients who underwent coronary angiography and were diagnosed as chronic coronary artery occlusion in combination with the state of hospitalization were selected as the CTO group.Another 190 patients who were diagnosed as non-CTO by coronary angiography at the same time were selected as non-CTO group.The general data,laboratory parameters and the degree of influence on left ventricular function and structure were compared between the two groups.Then the CTO group was divided into single vessel CTO disease group and multi vessel CTO disease group according to the number of diseased vessels.According to Rentrop score,the patients were divided into non coronary collateral circulation group(non).Left ventricular function was compared between CCC group and CCC group.Results :(1)there were significant differences in age,male ratio,positive rate of smoking history and incidence of diabetes between CTO group and non-CTO group(P< 0.05).Fasting blood glucose,hypersensitive C-reactive protein,serum cystatin and MPV,UA,WBC,HB,in CTO group and non-CTO group were compared with those in non-HDL-C,Cr,PDW,BUN,group.The multivariate logistic regression analysis showed that age,fasting blood glucose,serum cystatin and WBC,UA,MPV were the risk factors of CTO(P < 0 05).(2).The multivariate logistic regression analysis showed that age,fasting blood glucose,serum cystatin and WBC,UA,MPV were the risk factors of LDL-C(P < 0 05).The regression coefficients of CTO were 0.041,1.167,5.519,0.221,0.005,0.490;HB respectively,and the corresponding regression coefficient was-0.029.(3)ROC curve: the largest area was serum cystatin(0.784).The lowest UA,was 0.599(P < 0.05),the other indexes had certain predictive value(P < 0.05),and the other indexes also had some predictive value(P < 0.05).(4)correlation analysis: there was a positive correlation between WBC and serum cystatin(P < 0.05),and the correlation coefficient was 0.032(UA)and M(r=0.032).PV was positively correlated(P < 0.05),and the correlation coefficient was 0.032.(5)LV and LVEDV,the peak of A in CTO group was significantly higher than that in non-CTO group(P <0.05),and the E / A ratio in).CTO group was lower than that in non-CTO group(P < 0.05).(6)The LVEF,E peak and E / A ratio in single-vessel CTO disease group were higher than those in multi-vessel CTO disease group(P < 0.05).The LV,LVEDV of single-vessel CTO disease group was lower than that of multi-vessel CTO disease group(P < 0.05).(7)in CTO,LVEF in CCC group was higher than that in non-CCC group(P < 0.05),LVEDV,LV in).CCC group was lower than that in non-CCC group(P < 0.05).Conclusion :(1)Age,MPV,UA,WBC,FPG,CYS-C are independent risk factors for CTO,Hb is the protective factor of CTO.(2)MPV and UA,WBC and CYS-C can predict the occurrence of CTO.(3)The effect of CTO disease on left ventricular function and structure was more obvious than that of other cardiovascular diseases.(4)The effect of multi-vessel CTO lesion on left ventricular function and structure was more obvious than that of single-vessel CTO disease.(5)The effect of non-CCC group on left ventricular function and structure was more obvious than that of CCC group in CTO lesions. |
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