Correlation Between VCAM-1 And Gastrointestinal Stromal Tumor

Objective: To study the correlation between the expression of vascular cell adhesion molecule-1(VCAM-1)in tumor tissue of patients with gastrointestinal stromal tumors(GIST)and the risk degree of GIST and general clinicopathological factors.Methods: Ninety-six cases of gastrointestinal stromal tumor tissues were collected and the expression of VCAM-1 protein in tumor tissues was determined by immunohistochemistry(SP method),analysis of the correlation between VCAM-1 expression and tumor risk grade and general clinical case factors.Results: Among the 96 patients,37.5%(36/96)had high expression of VCAM-1 and correlated with tumor risk index and SMA expression(P<0.05),and the age,sex,tumor location,tumor size,degree of infiltration,CD34,CD117,DOG-1,S-100,Desmin and other factors have nothing to do(P>0.05).Conclusions: VCAM-1 may be highly expressed in gist and play an important role in the process of tumor development.The high expression of VCAM-1 is closely related to the risk scale of tumor.The detection of VCAM-1 expression level is helpful for the diagnosis,treatment and prognosis of GIST.