Study Of The Prognostic Correlation Between Preoperative AGR And Adult Primary Glioblastoma

Objective: Serum albumin levels(ALB)and albumin/globulin ratio(AGR)are reliable and convenient markers of the nutritional status,immunity and inflammation of human body,and preoperative ALB has been identified as a prognostic factor in the patients of glioblastoma(GBM).However,there are few studies has reported the prognostic correlation between preoperative AGR and primary adult GBM.Retrospective study preoperative AGR in adult primary GBM prognostic value.Methods: In this study,we analyzed,retrospectively,from 2013 to 2017 in our hospital underwent resection of126 cases of adult primary GBM patients with preoperative AGR and other related indicators and progression-free surial(PFS)and overall survival(OS),the relevance of the multiple factors analysis and Cox survival analysis to assess preoperative AGR's ability to predict the prognosis of patients with adult primary GBM.Results: Preoperative ALB(HR 0.342,95% CI,0.123–0.954,P=0.040)and postoperative adjuvant therapy(HR 0.042,95% CI,0.005–0.330,P=0.003)were significantly related to progression-free survival(PFS).Cox regression analysis showed the significance of adjuvant therapy(HR 3.579,95% CI,2.236–5.729,P<0.001).Preoperative AGR(HR 0.280,95% CI,0.103–0.763,P=0.013)and adjuvant therapy(HR 0.156,95% CI,0.047–0.513,P=0.002)were showed significance,and Cox regression analysis showed preoperative AGR(HR 1.810,95% CI,1.095–2.992,P=0.021)and adjuvant therapy(HR 4.702,95% CI,2.841–7.782,P<0.001)were independent predictors of overall survival(OS).Conclusion: Preoperative AGR was positively correlated with the prognosis of GBM.Patients with large preoperative AGR(?1.43)had longer OS.Postoperative adjuvant therapy is also an independent predictor of the prognosis of patients with primary glioblastoma.