Clinical Study On The Sedative Effect Of Midazolam In CT Examination Of Children

Purpose: To compare the clinical application effect of different sedative methods in CT examination of children.Method: A total of 60 children who had CT scans in the First Affiliated Hospital of Xinjiang Medical University from October 2017 to February 2018 were collected.Children were randomly divided into the K group(0.5ml/kg chloral hydrate enema combined with 0.5mg/kg intravenous ketamine)and the M group(0.5ml/kg chloral hydrate enema combined with 0.05mg/kg intravenous midazolam),with 30 cases in each group,and the hemodynamic indexes,sedative satisfaction,RSS score for sedation,sedative onset time,sedative awakening time and adverse reactions of the two groups were observed.Result: There was a statistically significant difference in RSS scores between the two groups after 10 min,20min and 30 min of administration(P < 0.05),and the RSS scores of the M group were better than those of the K group during CT examination.The differences in onset time,resuscitation time and total sedation time of children were statistically significant(P < 0.05).One child in group M had motion artifacts during CT scanning,while two children in group K had motion artifacts.There was no significant difference in the respiratory rate and blood oxygen saturation between the two groups(P > 0.05).There was a significant difference in the mean heart rate and blood pressure between the two groups(P < 0.05).During the period of medication and awakening,2 children in group K had restlessness,1 had respiratory depression,and 1 had nausea and vomiting.One child in group M had hypotension.Conclusion: compared with0.5ml/kg chloral hydrate enema combined with 0.5mg/kg intravenous infusion of ketamine,0.5ml/kg chloral hydrate enema combined with 0.05mg/kg intravenous infusion of midazolam in CT examination of children showed shorter and more stable recovery time.