Compares Dexmedetomidine And Midazolam For Sedation In Children

Ojective:Mzolam is the most commonly used premedication in children. We designed this prospective, randomized, controlled trial to evaluate whether intranasal dexmedetomidine is as effective as oral midazolam for premedication in children.Methods:One hundred children of ASA physical status I or II scheduled for elective minor surgery were randomly assigned to one of three groups. Group M received midazolam0.5mg/kg in5%glucose and intranasal placebo. Group D received intranasal dexmedetomidine1ug/kg, respectively, and5%glucose. Patients’ sedation status, behavior scores, blood pressure, heart rate, and oxygen saturation were recorded by an observer until induction of anesthesia. Recovery characteristics were also recorded.Results:there were no significant differences in parental separation acceptance, behavior score at induction between two groups. Compared with group M, patients in group D were significantly more sedated when they were separated from their parents (P <0.05). Patients from group D were significantly more sedated at induction of anesthesia when compared with group M (P<0.05).Conclusions:Iintranasal dexmedetomidine produces more sedation than oral midazolam,, but with similar and acceptable cooperation.