Clinical Characteristics Of Maxillofacial Manifestations Of Langerhans's Cell Histiocytosis

Objective: Langerhan's cell histocytosis(LCH)is a tumor-like disease with variable clinical characteristics that that are characterized by causing organ dysfunction.In this paper,the clinical characteristics of Langerhan's cell histocytosis were discussed firstly,then the differences between Langerhan's cell histocytosis and maxillofacial-related diseases were analyzed to help the early diagnosis;Finally,the treatment and prognosis of Langerhan's cell histocytosis were summarized.Methods: A retrospective survey was conducted in this study.A total of 51 patients with Langerhan's cell histocytosis having maxillofacial lesions who were treated at the First Affiliated Hospital of Xinjiang Medical University from 2013 to 2019 were collected.The clinical data were collected,including the clinical manifestations,imaging characteristics,treatment methods and the evaluation of the efficacy of different treatment methods,and the data were statistically analyzed using Microsoft Office Excel2013.Results: A total of 51 cases were collected in this study,and this disease was more common in males.The ratio of male patients to female patients was 1.55: 1,and this disease was more common in children,the proportion of children was 82%.Among them,the proportion of different ethnic groups in these cases was as following: the Han nationality accounted for 41.7%,the Uyghur nationality accounted for 37.25%,the Mongol nationality accounted for 5.88%,the the Hui nationality accounted for 5.88%,the Hasark nationality accounted for 3.92%,the Manchu nationality accounted for 1.96%,the Tajik Nationality accounted for 1.96%,and the Tujia nationality accounted for 1.96%.The occurrence sites of the maxillofacial lesions according to the proportion of predilection showed that: Posterior auricular mass,neck mass,temporal mass,frontal mass,mandibular bone lesions,external auditory canal pyorrhea,orbital mass,oral facial rash,parietal and occipital bone,submandibular mass,oral ulcers,zygomatic bone,maxillary bone.At present,the diagnosis is mainly based on the qualitative diagnosis of biopsy,followed by regular chemotherapy according to the guideline chemotherapy regimen,there are no reports of postoperative complications,and the curative effect is acceptable.Conclusion: Langerhan's cell histocytosis is difficult to differentiate due to its varied clinical characteristics.Definitive diagnosis depends entirely on pathological examination.However,due to the particularity of the disease itself,hidden symptoms of the maxillofacial region need to be taken seriously.Maxillofacial soft tissue tissue masses are often accompanied by irregular worm-like bone destruction.This imaging feature can help clinicians to diagnose as soon as possible and avoid the treatment success rate reduction caused by the delay of the disease.At present,the treatment of infants and young children patients relies mainly on chemotherapy,and the resection of lesions in adult patients can achieve the goal of cure.The disease progresses Langerhan's cell histocytosis rapidly in a short period of time without intervention.According to the retrospective analysis of the prone sites,it can be clinically differentiated from the common diseases in the oral and maxillofacial region,and found as soon as possible,so as to formulate the corresponding treatment plan.