Value Of PLR,NLR,MPVLR In The Diagnosis Of Acute Deep Vein Thrombosis

Objective: To evaluate the v alue of routine blood parameters including,platelet-to-lymphocyte ratio(PLR),neutrophil-to-lymphocyte ratio(NLR)and mean platelet volume-to-lymphocyte ratio(MPVLR)for patients with acute deep vein thrombosis(DVT).Methods:A total of 92 patients with unprovoked DVT of the lower extremities and 86 controls were recruited in this study.By comparing MPVLR,PLR,NLR and other indicators in the two groups to further evaluate the diagnostic value of the above indicators for acute deep venous thrombosis.Results: WBCs(P<0.001),neutrophil counts(P<0.001),MPVs(P=0.005),PLRs(P=0.019),NLRs(P<0.001),MPVLRs(P<0.001),were significantly higher in acute DVT patients compared to controls while the lymphocyte count(P<0.001)was lower than the control group.Notably,on multivariate logistic regression analysis,NLR and MPVLR were independent risk factors of acute DVT(OR: 9.690,P < 0.000 and OR: 7.162,P < 0.006).The under the curve(AUC)in NLR and MPVLR are 0.871 and0.963,respectively.The optimal NLR cutoff value is 2.15 for the diagnosis of acute DVT.At this time,the sensitivity is 89.1% and the specificity is84.9%.The optimal MPVLR cutoff value is 6.88 for the diagnosis of acute DVT.At this time,the sensitivity and specificity are 42.4% and 84.9%,respectively.These two indicators have certain value for the diagnosis of deep vein thrombosis.In addition,based on the onset time of the DVT,The chisquare test and the students t-test showed a statistically significant difference in the MPVLR index between the two groups(P = 0.025).Besides,The swelling days > 7-day group had a lower MPVLR index than The swelling days ?7-day group.Conclusion: MPVLR,NLR,white blood cell count,neutrophil count,lymphocyte count and MPV have potential diagnostic values for patients with unprovoked DVT,and NLR and MPVLR are independent risk factors related to DVT.Elevation of MPVLR is more valuable in the early stages of acute DVT(within 7 days).