Predictive Value Of Neutrophil-to-lymphocyte Ratio And Platelet-to-lymphocyte Ratio In The Prognosis Of Patients With Muscular-invasive Bladder Cancer Undergoing Laparoscopic Radical Cystectomy

Objective:To investigate the predictive value of preoperative neutrophil-lymphocyte ratio（NLR）and platelet-lymphocyte ratio（PLR）in the prognosis of muscle-invasive bladder cancer（MIBC）following laparoscopic radical cystectomy（LRC）.Methods:We retrospectively analyzed 118 MIBC patients who underwent LRC in The Affiliated Provincial Hospital of Anhui Medical University from 2016 to 2019.The patients were divided into four groups according to the median values of NLR and PLR in peripheral blood before operation.The chi-square test was used to compare the differences in clinicopathological feature among the different groups.The overall survival and relapse-free survival was analyzed by the Kaplan–Meier method,with differences analyzed by the log-rank test.Cox univariate and multivariate regression analysis was used to analyze the risk factors that affect the prognosis of MIBC patients.Results:According to the median value,the grouping thresholds of NLR and PLR were determined to be 2.33 and 115.00,respectively.High NLR and high PLR were significantly associated with p T stage and lymph node metastasis of bladder cancer（P<0.05）,and high PLR were also significantly associated with tumor size（P<0.05）.Both high NLR and PLR showed significant impact on the patients’ overall survival（P<0.05）,and high NLR was also significantly associated with the patients’ relapse-free survival（P<0.05）.In addition,multivariate regression analysis revealed that high NLR and p T stage were independent risk factors for patients’ overall survival and relapse-free survival.Conclusion:Preoperative high NLR and high PLR are related to the poor prognosis of MIBC patients undergoing LRC,which can be used as prognostic predictors in MIBC patients treated with LRC.