Correlation Study On The Relationship Between PLR,NLR And Retinopathy In Patients With Type 2 Diabetes Mellitus

ObjectiveTo investigate the correlation of inflammatory markers platelet-to-lymphocyte ratio,neutrophil-to-lymphocyte ratio and diabetic retinopathy?DR?in patients with type 2diabetes mellitus?T₂DM?.Methods257 patients with T₂DM admitted in our hospital from January 2016 to December2017 were randomly selected and divided into patients without DR?NDR group,n=80?and patients with DR?DR group,n=177?.DR group was also divided into non-proliferative diabetic retinopathy subgroup?NPDR,n=100?and proliferative diabetic retinopathy subgroup?PDR,n=77?.The age,sex,the duration of diabetes and other basic information of all the subjects were collected,and the indicators of fasting blood glucose,glycosylated hemoglobin,blood routine,blood lipid and renal function were detected,and PLR and NLR were calculated.The clinical value of PLR,NLR and other indicators in the diagnosis of DR in patients with type 2 diabetes mellitus was evaluated by using the independent sample t test and Receiver operating characteristic curve?ROC?.Results1.Compared with NDR group,the duration of diabetes,FPG,HbA1c,BUN,Cr,?2-MG,PLT,Neutrophil count,PLR and NLR in DR group were higher,but Lymphocyte count and TG were lower,and the difference was statistically significant?P<0.05?.Contrast NDR group and DR,sex,age,CHO,HDL-C,LDL-C and white blood cell,no statistical significance?P>0.05?,that is not associated with diabetic retinopathy.2.Compared with the NPDR group,FPG,Neutrophil count,PLR and NLR in PDR group were all increased,Lymphocyte count was lower,and the difference was statistically significant?P<0.05?.There was no statistically significant difference between the remain-ing indicators?P>0.05?.3.ROC curve was used to evaluate the clinical value of Neutrophil count,Lymphocyte count,PLR and NLR in the diagnosis of diabetic retinopathy in patients with type 2 diabetes.The area under the curve?AUC?of Neutrophil count for the diagnosis of DR in type 2 diabetes were 0.608[95%CI?0.535,0.682?],the optimal cut-off value was2.945mmol/L,with a sensitivity of 80.8%and a specificity of 38.7%.The area under the curve?AUC?of Lymphocyte count for the diagnosis of DR in type 2 diabetes were0.650[95%CI?0.575,0.726?],the optimal cut-off value was 2.495mmol/L,with a sensitivity of 38.8%and a specificity of 89.3%.The area under the curve?AUC?of PLR for the diagnosis of DR in type 2 diabetes were 0.711[95%CI?0.646,0.776?],the optimal cut-off value was 96.483,with a sensitivity of 76.3%and a specificity of 57.5%.The area under the curve?AUC?of PLR for the diagnosis of DR in type 2 diabetes were 0.722[95%CI?0.658,0.785?],the optimal cut-off value was 2.038,with a sensitivity of 45.2%and a specificity of 88.7%.ConclusionPLR and NLR are related to the occurrence and development of diabetic retinopathy?DR?in patients with type 2 diabetes mellitus,and have a more important clinical value for the diagnosis of DR.Inflammatory markers NLR and PLR are elevated in patients with DR in type 2 diabetes mellitus,suggesting that inflammation may be associated with diabetic retinopathy.