Urinary Ionomic Analysis Reveals New Relationship Between Minerals And Longevity In A Han Chinese Population

Healthy aging and longevity are the goals of human being,and it has been a hot and difficult point of research.Genetic,nutritional,environmental and many other factors play a key role in healthy aging and human longevity.With the continuous development of science and technology,the researchs on the molecular mechanism of healthy aging and longevity have been deepened,and a series of important achievements have been made.The complex relationship between the metabolic process and homeostasis of various minerals and longevity are attracting more and more attention.However,most studies focused on the relationship between some essential trace elements and aging,ignoring the complex and dynamic relationship between elements.In this study,we carried out a network-based approach to investigate the urinary ionome of nonagenarians and centenarians(longevity group)when compared with their biologically unrelated and younger family members(control group)from a Han Chinese population.Several differentially changed elements were identified,almost all of which showed an elevated level in the longevity group.Correlation analysis of the ionome revealed significant element-element interactions in each group.We then divided each group into distinct subgroups according to age ranges,and built the elemental correlation network for each of them.Significant elemental correlations and correlation changes involving all examined elements were identified within or between different subgroups,implying a highly dynamic and complex crosstalk among the elements during human life.Finally,more similar elemental patterns were observed between extremely old and middle-aged people.Overall,our data reveal new relationship between urinary minerals and human longevity,which may extend our understanding of the mechanism of healthy aging.