Reward Process In Bipolar Disorder:Evidence From ERP

One of the most important clinical symptoms of bipolar disorder is excessive spending,which brain image studies have linked to abnormal activation of brain areas associated with reward in bipolar disorder.However,there are few studies on the reward mechanism of bipolar patients using ERP at home and abroad.This study aims to explore the neural mechanism of reward in bipolar disorder compared with the healthy control group.According to the convenient sampling method,26 hospitalized patients who met the inclusion criteria and 25 healthy subjects who matched the demographic characteristics were selected.Firstly,The Young Mania Rating Scale,Hamilton Depression Scale,Hamilton Anxiety Scale were assessed the emotional state of the subjects,demographic information of the subjects and the patient's medical history and other information were collected.Secondly,The participants filled out The Barratt Impulsivity Scale and Buss-Perry Aggression Questionnaire.Finally,the subjects completed the Money Incentive Delay task and the Single Outcome Gambling after passing the exercise task,and recorded the ERP data of the Money Incentive Delay task.The results showed that the BIS-11 scale 's score,response time of two tasks of bipolar disorder group and the control healthy group had statistically significant differences,while the BPAQ scale,three components' amplitude of N1,N2 and P3 had no significant differences.Motor impulsivity?BIS-11 total score and the Money Incentive Delay task's response time were moderately correlated.The main effects of reward types in N1,N2 and P2 were significant.People with bipolar disorder were more impulsive and aggressive than healthy control group,but their behavioral responses were slower than healthy control subject.This is also consistent with the clinical symptoms of bipolar disorder as impulsive,but anticlimax and behaviors end in failure.Compared with the control healthy group,the N1,N2 and P2 of the bipolar disorder group had larger average amplitude and they consumed more cognitive resources,but there was no significant difference in the average amplitude between the two groups.This suggests that bipolar disorder are prone to impulsivity and attack others,which is consistent with the clinical manifestations of manic episodes.Bipolar disorder may have defects in reward feedback processing,which provide reference for the diagnosis and treatment of bipolar disorder.