Predictive Value Of Coronary Artery Lesion Severity Using CHADS2,CHA2DS2-VASc And CHA2DS2-VASc-HSF Scores

Objective:To explore the value of CHADS₂,CHA₂DS₂-VASc and CHA₂DS₂-VASc-HSF Scores for prediction of coronary artery lesion severity.Methods:A total of 542 consecutively admitted patients who underwent coronary angiography in Shengjing Hospital of China Medical University were selected.According to the clinical data,CHADS₂,CHA₂DS₂-VASc and CHA₂DS₂-VASc-HSF Scores were calculated.SYNTAX Score was calculated based on the results of CAG.Patients were divided into 2 groups including mild&moderate lesion group?n=506?and severe lesion group?n=36?according to SYNTAX Score.The biochemical indexes of the patients in the 2 groups were measured and compared to identify the risk factors of coronary artery lesion severity using logistic regression.Furthermore,AUC were calculated to access the predictive ability of three kinds of scores using ROC curve.Results:Type 2 diabetes mellitus[OR=3.401,95%CI?1.214-9.527?,P=0.020]and CHA₂DS₂-VASc-HSF Score[OR=2.100,95%CI?1.163-3.792?,P=0.014]were the independent risk factors of coronary artery lesion severity.The CHADS₂,CHA₂DS₂-VASc and CHA₂DS₂-VASc-HSF Scores were positively correlated with the coronary artery lesion severity?r=0.111,0.218,0.232 respectively,P=0.009,0.000,0.000 respectively?.For prediction of severe coronary artery lesion,the AUC of CHADS₂,CHA₂DS₂-VASc and CHA₂DS₂-VASc-HSF Score were 0.715?0.732 and 0.781,the optimal cut-off value of CHA₂DS₂-VASc-HSF Score was 4.50with a sensitivity of 80.6%and a specificity of 63.0%?AUC:0.781,95%CI:0.721-0.842,P=0.000?.Conclusion:Type 2 diabetes mellitus and CHA₂DS₂-VASc-HSF score were the independent risk factors of coronary artery lesion severity.Three kinds of scores were positively correlated with SYNTAX Score.CHADS₂,CHA₂DS₂-VASc and CHA₂DS₂-VASc-HSF Score can be used as valuable indicators of severe coronary artery lesion,especially CHA₂DS₂-VASc-HSF score>4.5.