Pathogenic Distribution And Drug Resistance Analysis Of Peritoneal Isolated Specimens From 2016 To 2018

Objective: To analyze the distribution of pathogenic bacteria and drug sensitivity in abdominal cavity samples of patients with intra-abdominal infection in our hospital,and to provide a better theoretical basis for clinical application of antibiotics in the treatment of abdominal infection.Methods: Collection and analysis from shengjing hospital affiliated to China medical university on January 1,2016-December 31,2018,three years more than 14 one full year of life in patients diagnosed with celiac infection of isolated specimens of 1732 cases of abdominal cavity with a standard biochemical test and CLSI recommendation for microbial identification and antimicrobial susceptibility test(excluding repeat isolates in the same patients).The drug sensitivity data were analyzed and screened by Excel software,and the comparison between groups was conducted by chi-square test,P < 0.05 was considered as significant difference.SPSS24.0 software was used for statistical analysis of the results.Results: The data analysis of this study showed that the types of pathogenic bacteria isolated from the abdominal cavity of our hospital were complex and diverse.The proportion of gram-negative bacteria was the highest(69.92%),followed by gram-positive bacteria(27.71%)and fungi(2.37%).The first four gram-negative bacilli were escherichia coli,klebsiella pneumoniae,acinetobacter baumannii and pseudomonas aeruginosa,respectively,with the detection rates of 26.33%,18.94%,7.04% and 6.76%.The first four strains of gram-positive bacteria were successively enterococcus faecalis,enterococcus faecalis,coagulase negative staphylococcus and staphylococcus aureus,with detection rates of 11.37%,4.68%,4.51% and 4.21%,respectively.ESBL positive rate of escherichia coli was significantly higher than that of klebsiella pneumoniae,and 11 strains of escherichia coli and 12 strains of klebsiella pneumoniae resistant to imipenem were found.MRSA accounted for 24.4% of staphylococcus aureus,while MRCNS accounted for 61.2% of coagulase negative staphylococcus aureus.Both staphylococcus aureus and coagulase negative staphylococcus had low drug resistance rates to rifampicin and gentamicin.No vancomycin-resistant staphylococcus aureus and linidazoline-resistant staphylococcus aureus were found in this study.The proportions of enterococcus faecalis and enterococcus faecalis in enterococcus enterococcus were 29.14% and 70.86%,respectively.There were 6 strains of enterococci resistant to vancomycin,including 2 strains of enterococcus faecalis and 4 strains of enterococcus faecalis,and 2 strains of enterococcus faecalis resistant to linezolid.The main fungal infection in abdominal cavity was candida albicans,which was still highly sensitive to fluorouracil and had a drug resistance rate of 0%.Conclusion: The continuous evolution of antimicrobial resistance patterns in bacteria necessitates continuous updating of data on antimicrobial susceptibility profiles to ensure the safety and efficacy of pathogen specific antimicrobial therapies.More data from such studies in our hospital will help the physicians to select antibiotic therapies for intra-abdominal infection that are appropriate and specific for their location.