Study On The Relationship Between Serum Folic Acid, Vitamin B12 With Multiple Sclerosis And Neuromyelitis Optica

Objective: By comparing the patients with multiple sclerosis and neuromyelitis optica with healthy controls of the levels of serum folic acid and vitamin B12,to explore if there is a difference between serum folic acid and vitamin B12 of the patients with MS and NMO with healthy people.And then discusses whether we can affect the level of serum folic acid and vitamin B12 for affecting the development of MS and NMO.Methods: Collected 76 patients that diagnosed with MS and 80 patients that diagnosed with NMO(MS group and NMO group)from 2014 to 2019 in our hospital.Physical examination patients admitted to our hospital were set as control group,among which 55 cases were MS control group and 102 cases were NMO control group.All patients were collected fasting blood on the first or second day and then test the serum folic acid and vitamin B12 levels in each group.The serum folic acid and vitamin B12 levels of the MS group and the NMO group were respectively compared with those of the control group,for statistical significance.Then the MS group,NMO group and control group were divided into subgroups according to gender,age and duration of disease,and the serum folic acid and vitamin B12 levels of each subgroup were compared to analyze whether there was statistical significance.All data were statistically analyzed by spss21.0software.Results: The serum folic acid levels of the MS group and NMO group were lower than those of the control group.The serum vitamin B12 levels of the MS group were lower than those of the control group.The serum vitamin B12 levels of the NMO group were higher than those of the control group.Two independent sample t tests were conducted for MS group,NMO group and control group respectively: serum folic acid and vitamin B12 of MS group were lower than those of control group,and the difference was statistically significant(P<0.05).Serum vitamin B12 level in NMO group was slightly higher than that in control group,but the difference was not statistically significant(P>0.05).The serum folic acid level in NMO group was lower than the control group,and the difference was statistically significant(P<0.05).Compared with male and female patients in MS group,the difference in vitamin B12 level was not statistically significant(P>0.05).Folic acid levels in males were lower than that in females,and the difference was statistically significant(P<0.05).Compared with male and female patients in the NMO group,the differences in folic acid and vitamin B12 levels were not statistically significant(P>0.05).The MS group and MS control group were compared in male and female population,and the differences in folic acid and vitamin B12 levels between the MS group and the control group in the male population were not statistically significant(P>0.05).In the female population,compared with the control group,the levels of folic acid and vitamin B12 in the MS group were lower than those in the control group,and the difference was statistically significant(P<0.05).The NMO group and the NMO control group were compared in male and female population respectively,and the differences in folic acid and vitamin B12 levels between the NMO group and the control group in the male population were not statistically significant(P>0.05).Compared with the control group,folic acid level in the NMO group in the female population was lower than that in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in vitamin B12 levels(P>0.05).Patients in different age groups were compared in the MS group,there were no statistically significant differences in folic acid and vitamin B12 levels between groups younger than 40 and older than 40(P>0.05).There were no statistically significant differences in folic acid and vitamin B12 levels between groups younger than 40 and older than 40 in the NMO group(P>0.05).The MS group was compared with the MS control group in the population under 40 years old and the population over 40 years old,and the folic acid level of the MS group in the two age groups was lower than that of the MS control group,the difference was statistically significant(P<0.05).The vitamin B12 level of the MS group was lower than that of the MS control group in the group younger than 40 years old(P<0.05).In the population over 40 years old,there was no significant difference in vitamin B12 levels between the MS group and the MS control group(P>0.05)The NMO group and the NMO control group were respectively compared in the population under40 years old and the population over 40 years old.The folic acid level of the NMO group in both age groups was lower than that of the NMO control group,and the difference was statistically significant(P<0.05).There was no significant difference in vitamin B12levels(P>0.05).Comparison was made between the MS group and the NMO group with the duration of disease less than 3 years and the duration of disease more than 3 years.There were no statistically significant differences in folic acid and vitamin B12 levels between the MS group and the NMO group with the duration of disease less than 3 years and the duration of disease more than 3 years(P>0.05).Conclusion: Serum folic acid and vitamin B12 levels were decreased in MS patients and serum folic acid levels decreased in NMO patients.Serum folic acid and vitamin B12 levels may be associated with MS and NMO.Serum folic acid and vitamin B12 levels in MS and NMO patients were not associated with age or duration of disease.