The Association Between Cadmium Exposure And Diabetes,and Study On The Preliminary Mechanisms

Objective:To investigate current status of cadmium exposure in Chinese general adults,explore correlations and mechanisms between cadmium exposure and diabetes.Materials and Methods:The population data originated from SPECT-China 2014.We screened out 5733 adults according to criteria.Linear regression and logistic regression were used to analyze correlations between variables.In the animal experiment,we set 3 degree of cadmium exposure to Wistar rats.After 8 weeks exposure,we conducted intraperitonealglucose tolerance test and intraperitonealinsulin tolerance test and detected fasting insulin level.Blood cadmium level was measured by atomic absorption spectrometry.Results:1.Medians(interquartile range)of blood cadmium level was 1.70(0.58-3.62)ug/L.In the adjusted model,blood cadmium level was positively related to fasting plasma glucose.Meanwhile,the prevalence of prediabetes was increased according to the increase in blood cadmium tertiles.2.In animal experiment,after 8-weeks cadmium exposure,areas under the curve in intraperitonealglucose tolerance test of low-dose exposure group(B group)and high-dose exposure group(C group)were significantly higher than control group(A group).B group has significantly higher fasting insulin level than A group.Conclusions:In conclusion,blood cadmium level in Chinese adults was much higher than in other developed countries.Cadmium exposure may be one pathogenic factor of diabetes.Inducing insulin resistance and injuring glucose-induced insulin secretion may be mechanisms.Further studies were needed to clarify the underlying mechanisms.