Clinical Study Of Early Individualized Fluid Resuscitation Combined With Norepinephrine Therapy For Septic Shock

Objective Septic shock refers to shock caused by infection of pathogenic microorganisms,which is one of the common types of shock in clinical practice.It is a severe tissue hypoperfusion state caused by impaired microcirculation and cellular hypoxia caused by infectious systemic inflammatory reactions,including severe hypovolemia,vasodilation,and cardiac insufficiency.One of the most common causes of death among inpatients in the intensive care unit(ICU).Liquid management of septic shock has been the focus of attention,fluid management from untargeted fluid management to early target-directed fluid management,and the prognosis of severe infections has increased.However,with the further study of EGDT by scholars,people began to question the EGDT,not only in improving the prognosis,but also in questioning the adverse reactions and target indicators of EGDT.This study compared the use of early individualized fluid resuscitation strategy with norepinephrine compared with EGDT to improve the prognosis of patients with septic shock.Methods From December 2016 to November 2017,patients with septic shock who were admitted to the emergency intensive care unit(EICU)of the Affiliated Hospital of Hebei University in parallel with the EGDT program were selected as the control group.They were admitted to Hebei University from December 2017 to October 2018.The septic shock patients in the hospital EICU were the experimental group,and the individualized fluid resuscitation program was given to the experimental group patients.The prognosis of the two groups was compared.Results There were no significant differences in age,gender,underlying disease,infection,SOFA score,APACHE II score and 6 h lactate clearance between the two groups(P>0.05).Total fluid intake,acute kidney injury,and 28-day mortality in the experimental group.The rates were lower than the control group(P<0.05).Conclusion Early individualized fluid resuscitation combined with norepinephrine in septic shock can reduce the fluid intake of patients,reduce the risk of acute kidney injury,and improve the prognosis of patients.