The Expression And Clinicopathological Significance Of BRCA1 In Breast Cancer Of Young Women In Qinghai Province

Objective: To observe the expression of BRCA1 protein in breast cancer patients of young women and middle-aged and elderly women in Qinghai,and to explore its relationship with the clinicopathological characteristics and prognosis of breast cancer in young women in Qinghai.Methods: Collected in January 2014 to May 2018 in Qinghai university affiliated hospital specimens of breast cancer radical surgery resection,postoperative pathological diagnosis of patients with breast cancer of women 40 cases(age 35 years old or less),and collect the breast cancer radical surgery resection specimens during this period,the postoperative pathological diagnosis of breast cancer in elderly patients(aged 45-70)40 cases as control group.The clinicopathological data of the patients were recorded in detail,and immunohistochemical staining was performed on the wax blocks of all patients to observe the expression of BRCA1,ER,PR,her-2 and ki-67.Results: 1.There were statistically significant differences in tumor size,lymph node metastasis and clinical stage between the young group and the elderly group(p < 0.05).2.There were 29 cases(72.5%)of BRCA1 protein positive expression in the young group.There were 16 cases(40.0%)of BRCA1 positive expression in the elderly group,and the difference between the two groups was statistically significant(p < 0.05).3.There are differences in the expression of BRCA1 protein in the tumor size of young women with breast cancer,and the expression of BRCA1 protein tends to decrease with the increase of tumor diameter.4.Lymph node metastasis(p=0.036)is a factor affecting the overall survival of breast cancer in young women in Qinghai.However,the maximum tumor diameter,clinical TNM stage,vascular invasion,molecular typing,histological grading,ER,PR,her-2,ki-67 and BRCA1 protein expression were not correlated with the disease-free survival and total survival of the patients(p > 0.05).Conclusion: 1.The detection rate of breast cancer among young women in Qinghai was 5.5%.2.The tumor diameter,lymph node metastasis rate and clinical stage of breast cancer were larger in young women in Qinghai.Histological grading is higher; Luminal B molecular typing more.3.The positive expression rate of breast cancer BRCA1 protein in young women in Qinghai was 72.5%,and the positive expression rate was higher than that in the elderly group.The expression of BRCA1 protein may not be correlated with any clinicopathological factors.4.The disease-free survival and total survival of young women with breast cancer in Qinghai region may be unrelated to the expression of BRCA1 protein,but the total survival is related to lymph node metastasis.