Differential Analysis Of Cognitive Function In Patients With Different Subtypes Of Chronic Insomnia And Its Correlation With Sleep Parameters

ObjectiveTo explore the differences in cognitive function between different subtypes of chronic insomnia,including the diferences of incidence of cognitive dysfunction and the cognitive domain of each subtype.To analyze the correlation between cognitive function and objective sleep parameters.MethodsTo collect patients diagnosed as chronic insomnia in the neurology department of Cardiovascular and Cerebrovascular Hospital of Ningxia Medical University from January 2018 to December 2018(65 cases in total).Polysomnography(PSG)was used to classify patients with insomnia objectively.14 cases were sleep difficultly,12 cases were awakened early,16 cases were difficult to maintain,and 23 cases were mixed.On the morning of the completion of PSG,to evaluate the cognitive function of patients with the Montreal Cognitive Assessment(MoCA).TO find out the differences in cognitive function and its correlation with sleep parameters in patients with chronic insomnia.Results1.The incidence of cognitive impairment in different subtypes of chronic insomnia was different(X~2=8.004,p<0.05),and the mixed group was more prone to cognitive dysfunction.2.The delayed recall scores of patients with different subtypes of insomnia were different(H=13.239,p<0.05),and the scores of the mixed group were lower than other groups(p<0.05).3.Partial correlation analysis of all patients showed that the directive force scores were positively correlated with total sleep time and sleep efficiency(r=0.302,0.275,P<0.05),and negatively correlated with N2%(r=-0.321,P<0.05).The attention scores were positively correlated with sleep efficiency,REM time,REM%,N3+N4 time,(N3+N4)%,N2%(r=0.277,0.313,0.308,0.268,0.255,0.258,P<0.05).The naming scores were positively correlated with sleep efficiency(r=0.289,P<0.05).The scores of visual and executive function were positively correlated with total sleep time,sleep efficiency and REM%(r=0.295,0.329,0.261,P<0.05).Delayed recall scores were positively correlated with total sleep time,sleep efficiency,REM time,and REM%(r=0.419,0.440,0.581,0.621,P<0.05),and negatively correlated with sleep latency(r=-0.302,P<0.05).Abstractive power scores were positively correlated with sleep efficiency,REM time,and REM%(r=0.260,0.306,0.325,P<0.05),and negatively correlated with sleep latency(r=-0.313,P<0.05).MOCA scores were positively correlated with total sleep time,sleep efficiency,REM time,REM%,N2%and N3+N4 time(r=0.478,0.557,0.591,0.643,0.268,0.253,P<0.05),and negatively correlated with sleep latency(r=-0.282,P<0.05).Conclusion1.The incidence of cognitive dysfunction among different subtypes of chronic insomnia was different,the mixed type was more prone to cognitive impairment.2.There was a correlation between cognitive domain function with total sleep time and sleep efficiency.3.Delayed recall,abstract power,and attention were all related to REM sleep.Attention was related to slow wave sleep.