Analysis Of Clinical Data Of 165 Newly Diagnosed Multiple Myeloma

Objective: To study the clinical features of multiple myeloma,including clinical manifestations,laboratory tests and imaging studies,to summarize early diagnosis experience To investigate.Methods: To collect clinical data of patients with multiple myeloma who were newly diagnosed in the Department of Hematology,Ningxia Medical University from January 2012 to December 2017,and to view and statistically analyze the laboratory report,bone marrow puncture test results and imaging examination report in the medical records.Single,disease record and other related data,analysis of the diagnosis of multiple myeloma and the clinical characteristics of different types of multiple myeloma.Results: Gender and age distribution: The age of 165 patients with multiple myeloma was 36-78 years old,with an average of(58.04±5.74)years old and 22 cases less than 40 years old,accounting for 13.3%,112 cases were 40-65 years old,accounting for 67.9%,and31 cases were older than 65 years old,accounting for 18.8%.Among them,108 males,aged36-78 years,mean age(59.7±5.45)years old,57 females,aged 39-72 years,mean age(55.1±4.21)years old.The ratio of male to female is 1.89:1.Clinical classification: Ig G type 72 cases(43.6%),Ig A type 42 cases(25.5%),light chain type 39 cases(23.6%)),Ig M type 6 cases(3.7%),Ig D type 3 cases(1.8%),non-secretoryno(1.8%),Ig E and double cloned type.Hot spots of onset: 65 cases with fatigue and dizziness,accounting for 39.4%,47 caseswith bone pain,accounting for 28.5%,46 cases with double lower extremity edema,abnormal urine test,abnormal renal function,accounting for 27.9%,15 cases with fever and cough.Accounted for 9.1%,physical examination abnormalities in 14 case,accounting for 8.5%.Experimental examination: anemia: Hb <100g / L or lower than the lower limit of normal 20 g / L 110 cases(66.7%),thrombocytopenia: PLT <100×109 / L a total of 22 cases(13.3%);renal dysfunction: creatinine >177umol/L 57 cases(34.5%);blood calcium increased: Ca>2.75mmo/L,29 cases(17.6%);imaging showed 78 cases of bone destruction(47.3%).There were 153 cases(92.3%)with elevated ?2-MG(>3.0 mg/L).Conclusion: Multiple myeloma due to insidious onset,complex and diversified clinical manifestations,easy to cause misdiagnosis and missed diagnosis,improve the comprehensive understanding of multiple bone marrow,timely comprehensive laboratory and imaging examinations,help early multimyeloma Confirmed diagnosis.