Cross-sectional Study On Relationship Between Drinking And Diabetes And Pre-diabetes In Residents Of Baota District,Yan'an City

Objective:To explore the relationship between alcohol drinking and diabetes mellitus(DM)and pre-diabetic(IGR)in Baota district of Yanan city,so as to provide a theoretical basis for DM patients to advocate rational and healthy lifestyle and prevent and cure DM and IGR.Methods:According to the method of epidemiological investigation,1,450 residents aged 20-74 years old in Baota District of Yan'an City were randomly selected according to the level of economic development.After obtaining informed consent,relevant questionnaires,physical examination and biochemical examination were conducted.According to the diagnostic criteria of DM and glucose metabolic status classification recommended by the World Health Organization(WHO)in 1999,the subjects were divided into normal blood glucose group(n = 851),IGR group,n = 302),DM group,n = 10 9).The subjects were divided into five groups according to their age: 20 years old ~ group(n = 311),30 years old ~ group(n = 327),40 years old ~ group(n = 332),50 years ~ group(n = 181),60 years old ~ group(n = 111),and DM,between the five groups.There was a statistically significant difference in the prevalence of IGR with age(p < 0 05).The prevalence of DM and IGR increased gradually.According to the guidelines for diagnosis and treatment of non-alcoholic fatty liver disease in China(revised edition 2010),the patients were divided into two groups according to the average daily alcohol intake: non-alcoholic fatty liver disease(0g/d),light alcohol intake(0.1-19.9g/d),non-alcoholic fatty liver disease,non-alcoholic fatty liver disease.There were 721 non-drinkers(man193,woman528),451(man273,woman178),and 90(man65,woman25)in the middle-heavy drinking group(? 20g/d),among which 721 were in the non-drinking group(man193,woman 528),451 in a small amount of alcohol(man 273,woman 178),and 90 in a moderate mass drinking group(man 65,woman25).The overall drinking rate was 42.9%,of which The drinking rate was 63.7% for males and 27.8% for females.The general data of all subjects were recorded,including age,sex,systolic blood pressure(SBP),diastolic blood pressure(DBP),BMI,DM history,DM family history,smoking history and so on.Serum uric acid(UA),total cholesterol(TC),was measured.Triglyceride(TG),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C)and other biochemical indexes were measured.Fasting blood glucose,(FPG),2h blood glucose(2h PG),)was measured.General information and biochemistry of different drinking groups The results showed that there was significant difference in age and total mean value of BMI,TC,TG,LDL-C among the three groups(p < 0.05),in which a small amount of drinking group was less than no drinking group < a large number of drinking group(P < 0.05).There was a significant difference in the total mean value of HDL-C among the three groups(p < 0.05),in which a small amount of drinking group was higher than that of non-drinking group.There was a significant difference in the total mean value of SBP among the three groups(p < 0 05),and there was a significant difference in the total mean value of FPG,2hPG among the three groups(p < 0 05),and that in the heavy drinking group was higher than that in the non drinking group and the light drinking group There was a significant difference in the total mean value of UA among the three groups(p < 0.05),and that in the middle-heavy drinking group was higher than that in the non-drinking group and the moderate-heavy drinking group(p < 0.05).According to sex and BMI,the prevalence of IGR and DM in different drinking groups were compared.The results showed that the prevalence of IGR and DM was lower in the drinking group than that in the non-drinking group,and that in the heavy drinking group(p < 0.05),the prevalence rate of IGR and DM in the drinking group was lower than that in the non-drinking group.With or without DM and IGR as dependent variables,sex,age,family history of diabetes mellitus,and BMI,alcohol intake as independent variables,as multiple factors.Logistic regression analysis showed that a small amount of alcohol consumption was the protective factor of IGR and DM after adjusting for confounding factors,and OR and 95%CI were 0.384(0.253? 0.478).Conclusion:1.Small alcohol drinking(0.1g/d < ethanol intake <19.9g/d)is a protective factor for IGR and DM disease,a large amount of alcohol consumption(ethanol intake ? 20g/ d)is IGR and DM disease The risk factor.2.Small alcohol drinking(0.1g/d < ethanol intake <19.9g/d)TC,TG,LDL-C value is lower,with the increase in ethanol intake(ethanol intake ? 20g/d),TC,TG,LDL-C values increase,it can be speculated that heavy drinking may be related to the risk of high TC,TG,LDL-C.