Clinical Efficacy Of Low-dose Aspirin In The Prevention Of Preeclampsia In High-risk Pregnant Women

Objective:To observe the clinical effect of low-dose aspirin on high-risk single-pregnant women,provide a clinical treatment to reduce the occurrence of PE,and better reduce adverse outcomes for pregnant women and perinatal children.Methods:From June 2017 to June 2018,choose the woman who was seen obstetrics at Yan'an University Affiliated Hospital.Pregnant time between 12-20 weeks(after verification by professional obstetricians)118 eligible high-risk single-pregnant women with a history of PE in the previous pregnancy were enrolled.Randomly divided into two groups(depending on random number table),the treatment group(58 cases)and the control group(60 cases).The treament group was given aspirin 100 mg/d(regularlly taken before bed every night)until pregnancy to 34 weeks.The control group received routine perinatal health care(active diet,exercise and other related treatments).Record general clinical data of all menbers;Record general information about all menmbers,Draw venous blood to test kidney function,liver function and Blood clot.Record creatinine(CRE),urea(Urea),albumin(ALB),alanine aminotransferase(ALT),aspartate Aminotransferase(AST),total bilirubin(TBi L),direct bilirubin(DBi L),prothrombin time(PT),activated partial thromboplastin time(APTT),plasma D-dimer quantification(D-Dimer),fibrinogen(FIB);record the gestational age of pregnant women,the number of PE cases,the number of weeks of PE,the number of placental abruption,the number of HELLP syndrome;record the birth weight of newborns,1 minute,5 minutes Apgar scores;statistical analysis of all data using SPSS 22.0.Results:1.There were no difference between the experimental group(n=60)and the control group(n=58)in age,number of gestational age,body mass index(BMI)and pregnancy times before childbirth.As table 1.2.Compare Liver function(ALT,AST,ALB,TBi L,DBi L,)and Renal function(Urea CRE)and Blood clot(PT,APTT,FIB?D-Dime)between the two groups in late pregnancy,(P>0.05)Result is there was no statistical difference.As table 1?table2?table3.3.There were no differences between the experimental group and the control group at the gestational weeks of childbirth and pregnancy.The differences of neonatal weight,preterm birth and low birth weight were statistically significant(P<0.05).There was no significant difference between Apgar score at 1 min and Apgar score at 5min(P>0.05).As table5?table6.4.Comparison of pregnancy complications between the experimental group and the control group showed that the incidence of preeclampsia was 6.9% in the experimental group and 33.3% in the control group,with a statistically significant difference of 0.05.There was no significant difference between the two groups(P>0.05).As table7.5.The gestational weeks of PE in pregnant women in each group were used as the observation index to draw the survival curve.The gestational weeks of PE in the experimental group were significantly lower than those in the controlgroup.As figure 1.Conclusions:1.Taking low-dose aspirin during 12-20 weeks of pregnancy has a preventive effect on the recurrence of high-risk PE,which can delay the onset of PE pregnancy,prolong the pregnancy,and reduce pregnancy complications.2.Small doses of aspirin during the 12-20 week gestational period do not harm the liver,kidney or coagulation function of the pregnant woman.3.Low dose of aspirin during 12-20 weeks of pregnancy has no adverse effects on gestational age,weight,apu scores and birth asphyxia of newborns.4.There was no significant improvement in pregnancy complications with low-dose aspirin during the 12-20 week gestational period.