Study On The Regulation Of Risperidone On Cerebral Electromyography

Schizophrenia is a relatively serious mental illness.Currently,clinical treatment is usually based on drugs.There are many types of drugs related to schizophrenia.The drug efficacy is mainly based on the patient’s subjective feelings and the doctor’s clinical experience,and there is no objective quantitative basis.With the rapid development of electronic information technology,new technologies such as EEG,brain magnetic,and magnetic resonance are gradually being used in clinical research.Among them,EEG has been widely used in the clinical diagnosis and treatment of mental diseases because of its advantages of non-invasive,high temporal resolution and low maintenance cost.This article mainly starts with electroencephalogram(EEG)to study the regulatory mode of second-generation drug risperidone on patients’ brain electricity.main results as follows:1.Power spectrum analysis: Welch method was used to estimate the EEG power spectrum.Then compare the spectrum values,brain topography and asymmetry before and after taking the drug.It was found that the patients with schizophrenia were treated with risperidone for a period of time.The power spectrum value of the α,θ,β frequency band is increased as a whole.The δ band power spectrum does not change significantly in each brain region,but it becomes smaller in the whole brain.The asymmetry of the δ and θ whole brain bands changed significantly.2.Brain network analysis: The brain network was constructed by coherent estimation,and the network parameters such as brain network connection intensity and feature path length,clustering coefficient,local efficiency,global efficiency,degree of centrality and median centrality were compared before and after taking the drug.It was found that after taking risperidone,brain network connections were significantly enhanced in the frontal,central,parietal,and temporal lobe regions.The clustering coefficient and local efficiency were mainly increased in the forehead,parietal and temporal lobe regions.The median centrality varies significantly in the frontal and temporal regions.The degree of centrality is significantly reduced in the frontal pole and significantly larger in the parietal region.The characteristic path length and global efficiency did not observe a significant change in each frequency band.By comparing the EEG power spectrum and brain network before and after taking risperidone,it was found that risperidone may has a positive regulation effect on EEG in patients with schizophrenia,and the alpha band may be used for drug efficacy evaluation.