Study On The Correlation Between The Efficacy Of SLT And Schlemm's Function In POAG Patients

Purpose:This study is plan to observe Schlemm's canal blood relux,record the intraocular pressure before and after exercise,measure the Schlemm's canal area expansion before and after exercise in primary open-angle glaucoma(POAG)patients eyes.Within three indicators above to evaluate Schlemm's canal function of patients with POAG and discuss the relationship between selective laser trabeculoplasty postoperative efficacyse and Schlemm's canal function.Method:(1)17 POAG patients,25 eyes.Before exercise,using the gonioscope to check whether the POAG eyes have blood reflux wihtin whole Schlemm's canal circle.Use non-contact tonometer to measure the intraocular pressure level.TOMEY-OCT was used for scaning 12 points,3 points,6 points and 9 points on the cornea to know whether the Schlemm's canal is opening and the area of the Schlemm's canal.After the exercise,POAG patients were measured the intraocular pressure with the non-contact tonometer in one minute,and making a comparing before and after the exercise.Use TOMEY-OCT again to scan cornea position froml2 o 'clock to 9 o'clock clockwise,and know whether the Schlemm's canal is opening and whether the area of the Schlemm's canal have expansion.(4)according to the patients' ocular examination,the patients were divided into three groups-the indicators were all positive(group 2),indicators were negative positive(group 1),and the indicators were all negative(group 0).(5)Instructed SLT treated patients with eye medication during the observation period with the same varieties,methods.The patients were told to review the intraocular pressure of the patients treated with SLT after 1 week,2 weeks and 4 weeks.(6)Using statistical software to compare differences.Result:(1)In the three groups of patients,the intraocular pressure was significantly decreased in the positive group(2 groups)and the negative positive mixed group(1 group).One month after the surgery,the two groups were compared with the preoperative period(14.38±3.25mmHg VS 22.29±4.78mmHg,P<0.001),1 group and preoperative comparison(19.00±4.07mmHg VS 25.76±9.04mmHg,P=0.003),and P<0.05 was statistically significant.In the three groups,after 1 month of SLT treatment,the intraocular pressure decreased significantly in group 2 and group 1.The comparison between group 2 and group 0(14.38++3.25mmHg VS 19.33+4.32mmHg,P=0.017).1 group and 0 group(19.00±4.07mmHg VS 19.33±4.32mmHg,P=0.045),P<0.05 was considered statistically significant.In the three groups,the decrease of intraocular pressure in the two groups was significantly lower than that in the first week of January(-7.91±4.43mmHg VS-3.54±6.48mmHg,P=0.033),and P<0.05 was statistically significant.(4)Among the three groups of patients,the decrease percentage of the patients in the group 2 after SLT treatment was statistically different from that in group 0,and P=0.0047 in 1 week,P=0.0072 in 2 weeks,and P=0.0014 in 4 weeks.Conclusion:Through this clinical observation,we conclude that the efficacy of Schlemm' s canal function is positively correlated with the efficacy of SLT.Schlemm ' s canal blood relux,,the decrease of intraocular pressure before and after the exercise,and the expansion of Schlemm' s canal before and after exercise can be used as an indicator for evaluating the function of Schlemm' s canal.At the same time,we believe that it is important and necessary to evaluate the function of Schlemm' s tube before SLT surgery,so as to reduce unnecessary damage to patients and reduce medical expenses.