Analysis Of Correlation Factors Of Syntax Score In Patients With Coronary Heart Disease:a Hospital-Based Population Study

Objective: The study aims to explore the correlation between SYNTAX score and risk factors in clinical profile of patients with coronary artery diseases(CAD),to evaluate the value of individual risk factors to SYNTAX score as independent predictors.Methods: Between May 2017 to January 2018,patients from The First Affiliated Hospital of China Medical University diagnosed with coronary artery disease were enrolled.After exclusion,a total of 495 patients were remained in the study.The patients’ general clinical profile was documented,including laboratory test results,cardiac echocardiography,wrist circumference measured by a soft ruler and coronary angiography.The SYNTAX score was determined based on coronary angiography.According to SYNTAX scores,patients were divided into low,medium and high score groups,of whom the difference were compared in terms of their wrist circumference and other related clinical profiles.For each potential factor,their correlation to SYNTAX score and CAD with high SYNTAX score(≥33)were analyzed and the confounding bias were adjusted via simple linear regression,multiple linear regression and Logistic regression models.Patients were further stratified based on gender,diabetes status,and BMI.The risk factor of coronary artery disease with high SYNTAX scores was analyzed in each subgroup.Results: A total of 495 patients were included in the study.There were statistically significant differences in age,HbA1 C,albumin,prealbumin,troponin I,brain natriuretic peptide,and left ventricular ejection fraction between the low,medium,and high SYNTAX score groups.According to the univariate analysis results,the selection variables were included in multiple linear regression,and found male(β=3.501,P=0.002),age(β=0.211,P<0.001),troponin I(β=0.147,P=0.045),serum sodium(β=-0.432,P=0.028),brain natriuretic peptide(β=0.007,P=0.002),BMI(β=-0.325,P=0.047),HbA1C(β=1.39,P=0.001)can significantly affect the SYNTAX score independently.Logistic regression of the above factors revealed that only age was associated with high SYNTAX score(≥33)coronary artery lesions(P=0.014).With each additional year of age,it predicts higher SYNTAX score(≥33)coronary artery lesions risk by 5.8%.With data stratification,the risk factors for male patients were found to be albumin and brain natriuretic peptide;the risk factors for female patients were age and HbA1 C.The risk factor for diabetes patients is BMI;the risk factors for non-diabetic patients are left wrist circumference and brain natriuretic peptide.The risk factors for patients with normal BMI were left wrist circumference,homocysteine and diabetes;no specific correlation factors were found in other subgroups.Conclusion: Gender,age,myocardial injury marker level,cardiac systolic function,diabetes status and obesity are associated with coronary artery complexity.Advanced age is a significant contributor to complex coronary lesions.This study found that the factors associated with complex coronary lesions in different populations according to the stratification of gender,diabetes status,and BMI.