Short-Term Safety Assessment Of Intraperitoneal Raltitrexed In Patients With Rectal Cancer

Objective:To investigate the short-term safety of raltitrexed intraoperitoneal perfusion in patients with rectal cancer undergoing laparoscopic Dixon surgery.Methods:Totally 175 patients with rectal cancer at the department of Colorectal Oncological Surgery,Shengjing Hospital of China Medical University were analyzed retrospectively from June 2016 to December 2017.All the patients were divided into raltitrexed intraperitoneal perfusion group?n=89?and saline intraperitoneal perfusion group?n=86?according to whether given raltitrexed intraperitoneal perfusion or not.The hematological indexs of the two groups before operation and 3 days after operation were recorded.The postoperative exhaust time and postoperative drainage volume within 24 hours were calculated.The postoperative complications including anastomotic leakage,peritoneal irritation sign,incision infection,pulmonary infection were evaluated.Results:The surgery was performed successfully in all patients.There were no significant differences in the sex??²=0.000,P=0.990?,depth of tumor invasion?Z=-0.590,P=0.556?,TNM stage?Z=0.081,P=0.936?or pathological type?Z=1.092,P=0.896?between the two groups.There were no significant differences in postoperative exhaust time[?75.49±3.97?h vs.?74.28±3.46?h,t=0.479,P=0.523)],postoperative drainage volume within 24 hours[?201.1±54.1?ml vs.?242.8±25.7?ml,t=0.338,P=0.656)],anastomotic leakage?1.1%vs.2.3%,?²=0.351,P=0.554?,peritoneal irritation signs?1.1%vs.2.3%,?²=0.351,P=0.554?,incision infection?2.2%vs.3.5%,?²=0.243,P=0.622?and pulmonary infection?2.2%vs.2.3%,?²=0.001,P=0.972?between the two groups.Additionally,There were no significant differences in the counts of erythrocytes[?3.56±0.27?×10¹²/L:?3.63±0.26?×10¹²/L,t=0.716,P=0.152],leukocytes[?7.63±0.20?×10⁹/L vs.?8.24±0.26?×10⁹/L,t=0.176,P=0.872),blood platelets[?170.13±20.12?×10⁹/L vs.?180.18±21.03?×10⁹/L,t=0.103,P=0.975],glutamic-pyruvic transsaminase[?13.25±2.31?U/L vs.?13.28±1.46?U/L,t=0.321,P=0.713],glutamic-oxalacetictranssaminase[?16.51±1.28?U/Lvs.?16.23±2.03?U/L,t=0.131,P=0.894]and creatine[?77.36±6.49??mol/L vs.?78.39±6.64??mol/L,t=0.499,P=0.519]3 days after operation between the two groups.Conclusion:Intraperitoneal raltitrexed in Dixon surgery exhibits high safety and less adverse reactions,and is easy to operate,which is an available method in clinic.