Predictive Effect Of Platelet Counts And Plasma D-dimer Levels On The Severity Of Acute Pancreatitis

Objective:To investigate the role of plasma D-dimer levels and platelet counts in patients with acute pancreatitis within 24 hours of admission,and to further compare the prognostic assessment of acute pancreatitis.Find simple and rapid indicators that can predict the various complications and severity of acute pancreatitis to improve the level of diagnosis and treatment.Methods:The clinical data of 100 patients with acute pancreatitis were collected.According to the platelet count level within 24 hours after admission,the patients were divided into platelet reduction group and control group by 135×10~9/L.Plasma D-dimer levels within 24 hours of admission were divided into a control group of<252 ug/L and a D-dimer elevation group of>252 ug/L.At the same time,according to whether it is severe acute pancreatitis,the patients were divided into SAP group and MAP group.Retrospective analysis was used to analyze differences in platelet counts and plasma D-dimer levels between patients with respiratory failure,heart failure,renal failure,pneumonia,acute pancreatic fluid accumulation,pancreatic necrosis,and SAP incidence.Platelet count levels and plasma D-dimer levels were compared between patients in the SAP and MAP groups.The receiver operating characteristic curve(ROC)of platelet count level and d-dimer level was plotted,and the predicted value of sap was compared by calculating the area under the curve(AUC).Predictive effects of platelet counts and D-dimer levels on various complications and severity of AP patients.Results:In 100 patients,the incidence of respiratory failure,acute pancreatic fluid accumulation,pancreatic necrosis,renal failure,heart failure,and pneumonia was higher in the thrombocytopenia group than in the control group.The incidence of SAP was also higher than that in the control group.Statistical significance(p<0.05).The incidence of respiratory failure,acute pancreatic fluid accumulation,pancreatic necrosis,renal failure,heart failure and pneumonia was higher in the D-dimer-raised group than in the control group.The incidence of SAP was also higher than that in the control group.The difference was significant(p<0.05).The reduction of platelet count and the increase in D-dimer ap patients were significantly higher than those of other patients.The platelet count of the MAP patients(200.44±72.695)was significantly higher than that of the SAP patients(113.43±50.526),and the plasma D-dimer level(603.98±819.063)was significantly lower in the SAP group than in the MAP group(1777.39±1570.417).Statistical significance(p<0.01).The ROC curve analysis showed that the AUC(0.843)of PLT was slightly larger than the D-dimer(0.824),suggesting that the predicted value of PLT for SAP is better than that of D-dimer,and the Z-test analysis shows that PLT and D-dimer to SAP The predictive effect was not significantly different on auc(p>0.05).Conclusions:1.Platelet counts and D-dimer levels within 24 hours of admission can predict respiratory failure in patients with acute pancreatitis and local complications(acute pancreatic fluid accumulation),two indicators for SAP There was no significant difference in predictive power,and patients with reduced platelet counts had a significantly increased incidence of renal failure and pancreatic necrosis.2.The incidence of adverse events was significantly increased in patients with AP with reduced platelet count and D-dimer at admission.3.The platelet count of patients with SAP was significantly lower than that of patients with MAP,and plasma D-dimer levels were significantly higher than MAP patient...