Correlation Analysis Among HBV Markers Of Serum,Virology,Liver Inflammation Of Chronic HBV Infection In Different Stages

Objectives: To compare the serological and virological characteristics of different stages of chronic HBV infection,to explore its correlation with liver inflammation,to assist liver biopsy to determine whether liver inflammation is active,and to guide the treatment of patients with chronic hepatitis B.Methods:319 untreated cases of chronic HBV infection in the Department of Infectious Diseases in Shengjing Hospital that affiliated to China Medical University from 2014 to 2018 were enrolled.Among them,80 patients with HBeAg-positive chronic HBV infection,66 patients underwent liver biopsy,98 patients with HBeAg-negative chronic HBV infection,73 patients underwent liver biopsy,102 patients with HBeAg-positive chronic hepatitis B,and 39 patients with HBeAg-negative chronic hepatitis B.ALT,hepatitis B surface antigen quantification,HBeAg,HBV DNA level were measured.Compare serological and virological characteristics of different groups and compare with liver inflammation.Results:The median HBsAg of all HBeAg-positive patients(including chronic HBV infection and chronic hepatitis B)was 4.07 Log10IU/ml,and the median HBV DNA was 8.1Log10IU/ml,which was higher than that of HBeAg-negative patients.The median number was 3.4 Log10IU/ml,4.2 Log10IU/ml,and the difference was statistically significant(P value was less than 0.05).Among the 182 HBeAg-positive patients,HBeAg and HBsAg levels in the HBV-infected group and the chronic hepatitis B group were significantly higher than those in the chronic hepatitis B group.The difference was statistically significant.In 137 HBeAg-negative patients,the HBV DNA levels in the chronic HBV-infected group and the chronic hepatitis B group were significantly lower than those in the chronic hepatitis B group in the HBV-infected group,and the difference was statistically significant(P value less than 0.05).The critical value of HBV DNA that distinguishes hepatitis activity is 4.64 Log10 IU/ml,sensitivity is 84.2%,and specificity is 76.5%.Conclusion: Serological and virological levels are different in different clinical stages of chronic HBV infection,and e-antigen-positive patients have higher levels of HBsAg and HBV DNA than e antigen-negative patients.In HBeAg-positive chronic HBV-infected patients,HBsAg and HBeAg levels are associated with liver inflammation,and lower HBsAg and HBeAg levels are predictive of liver inflammatory activity.In HBeAg-negative chronic HBV-infected patients,HBV DNA levels are associated with liver inflammation,and higher HBV DNA levels are indicative of liver inflammatory activity.