Clinical Correlation Between Subclinical Hypothyroidism And Cognitive Dysfunction In Patients With Chronic Comorbidity

Objective:To explore the correlation between subclinical hypothyroidism and cognitive function in patients with chronic comorbidity,and to analyze the cognitive function of patients and the effect of TSH level on cognitive function.In order to monitor the thyroid disease in the management of chronic comorbid patients,the changes of serum TSH in patients with subclinical hypothyroidism are monitored to remind the general practitioner to identify and evaluate the cognitive function of patients early.Method:The chronic comorbidity patients hospitalized in the inpatient ward of the First Affiliated Hospital of the Medical University from January 2018 to December 2018 were screened for serum TSH,FT3 and FT4 on the morning of the second day of admission.According to the thyroid function level of hospitalized patients,the included population was divided into three groups(normal thyroid function?mild subclinical hypothyroidism?severe subclinical hypothyroidism),and then evaluated for neurocognition on the next day,including the MMSE and the Mo CA.To analyze the relationship between thyroid function and cognitive dysfunction in patients in general inpatient wards,and to analyze the main cognitive domains affecting cognitive dysfunction by univariate analysis.Result:A total of 90 hospitalized patients were included in the study,and the baseline clinical indicators were comparable between the three groups.By assessing the cognitive levels of the two scales in the three groups of patients,it can be concluded that patients with chronic comorbidities and subclinical hypothyroidism are associated with cognitive function,but not with the degree of subclinical hypothyroidism.It was also found that the level of TSH in the subclinical hypothyroidism group(SCH group)was negatively correlated with the status of cognitive function(r=-0.335,P<0.05).In this study,smoking was considered to be a risk factor for subcognitive cognitive function.Conclusion:Chronic comorbidities with subclinical hypothyroidism can affect cognitive function.This study is aimed at screening patients with thyroid disease in the management of patients with chronic comorbidities,monitoring subclinical hypothyroidism and changes in serum TSH in the reference interval for patient-centered general practitioners to identify and assess cognitive function early.Clinical guiding significance.