| Objectives:In this study,vitamin C was administered at various times as a sour stimulant to thyroid cancer patients,in order to investigate the correlation between time of taking vitamin C and salivary gland function,and to further study the optimal time for vitamin C administration.Methods:This study collected and analyzed the differentiated thyroid cancer patients from September 2017 to August 2018 in the Department of Nuclear Medicine of the First Affiliated Hospital of China Medical University.Patients with differentiated thyroid cancer were treated with 131I after thyroidectomy.The enrolled patients were divided into three groups according to the admission time:group A?1h?,group B?6h?,and group C?24h?.Each group received vitamin C at different starting time?1h,6h,24h?after 131I treatment.Patients took 100 mg of vitamin C once every 3 hours for 5 days.All patients completed dynamic imaging of salivary glands within 1 month before 131I treatment and3-6 months after 131I treatment.The difference between the 15 min uptake rate and the percentage of excretion of each gland before and after 131I treatment was quantified by using computer technology.Statistical analysis was performed by single factor analysis,Pearson chi-square test and non-parametric test.P<0.05 was considered statistically significant.Results:A total of 143 patients were collected.Three patients did not complete the salivary gland examination before 131I treatment;one patient had salivary gland examination over 6 months after 131I treatment.The final eligible patients were 139,including 37 male patients?26.6%?and 102 female patients?73.4%?with an average age of 44.9±12.3 years.The bilateral submandibular glands'15 min uptake rate after 131I treatment was significantly lower than that before 131I treatment,and the difference was statistically significant?P<0.05?.The 15 min uptake rate and percentage of excretion of bilateral parotid glands and percentage of excretion of bilateral submandibular glands before and after treatment were not significant differences?P>0.05?.The results showed that with vitamin C taken at different starting times,the 15 min uptake rate and percentage of excretion of bilateral glands and bilateral submandibular glands were not significant differences?P>0.05?.Furthermore,patients in groups A,B and C were divided into low-dose group?30mCi,50mCi?,medium-dose group?75mCi?and high-dose group?100mCi,150mCi,200mCi?according to the dose of iodine.Non-parametric test was performed on patients in different subgroups of the 3 groups.There were no significant differences in the 15 min uptake rate and the percentage of excretion of the bilateral parotid glands and the bilateral submandibular glands within the subgroups of the A,B,and C groups?P>0.05?.Conclusions:In patients with differentiated thyroid cancer after thyroidectomy,the 15min uptake rate of the submandibular gland was statistically significant when 131I was treated,which means 131I still caused a certain degree of damage to the submandibular gland function even when patients were given vitamin C.When vitamin C stimulation was given at different starting times,there were no significant differences in salivary gland functions.When the starting time of vitamin C is fixed,the effect of different 131I treatment dose on salivary gland function was not statistically significant. |
PDF Full Text Request