Normal References Of Right Ventricular Strain Values By Cardiac Magnetic Resonance Tissue Tracking

Objective: This study aims to determine the number of 112 healthy volunteers' s normal references of right ventricular strain values and strain rate by tissue tracking cardiac magnetic resonance.Materials and Methods: A cohort of 112 healthy subjects who meet the following inclusion criteria are recruited from the first affiliated of china medical university.A cohort of 100 healthy volunteers each decade of life between the 20 and 70 are divided into five groups and each group has twenty volunteers.The subjects have no contraindications of MRI examination,routine ecg examination showed sinus rhythm and no other abnormality,without known congenital or acquired cardiovascular disease,hypertension,diabetes,dyslipidaemia and systemic inflammatory disorders,informed consent to this study underwent cardiac magnetic resonance tissue tracking(CMR-TT)assessment of right ventricular(RV)myocardial strain and strain rate.Their LV systolic and diastolic function are normal.Results:(1)Cardiac magnetic resonance tissue tracking has good repeatability(global radial strain,GRS,Intra-observer ICC=0.97,Intre-observer ICC=0.99;global longitudinal strain,GLS,Intra-observer ICC=0.99,Intre-observer ICC=0.86;global circumferential strain,GCS,Intra-observer ICC=0.99,Intre-observer ICC=0.90).(2)Normal parameters of right ventricular myocardial strain and strain rate.Specific data results are shown in table3.(3)The correlation between right ventricular myocardial parameters and gender,age,BMI.(1)There were significant gender differences in the global radial strain,global circumferential strain,global circumferential strain for basal,global circumferential strain for mid in the right ventricle(24.9±8.7vs20.7±7.7,P=0.009 ?-14.2±4.1vs-12.3±3.9,P=0.014 ?-14.8±4.5vs-13.0±4.0,P=0.033 ?-13.5±4.7vs-11.2±4.4,P=0.011)with greater deformation in females than in males.(2)There were significant gender differences in the radial diastolic strain rate and circumferential diastolic strain rate(-1.4±0.5vs-1.2±0.5,P=0.026?0.8±0.2vs0.7±0.2,P=0.027)with greater deformation in females than in males.(3)there was no significant gender correlation between the global longitudinal strain and the longitudinal diastolic and systolic strain rate(-25.1±5.2vs-23.4±3.8,P=0.056 ?-1.7±0.6vs-1.5±0.6,P=0.178?1.3±0.3vs1.4±0.4,P=0.117).(4)there is a correlation between the global circumferential strain,global circumferential strain for basal,radial diastolic strain rate,circumferential diastolic strain rate and age.(5)There was no significant correlation between right ventricular myocardial strain,strain rate and BMI(P>0.05).Conclusion:(1)The normal range of myocardial strain values obtained in 112 healthy people can provide quantitative basis for clinical judgement of myocardical dysfunction.(2)The correlation between right ventricular myocardial parameters and gender,age,BMI.(1)the parameters of the overall and partial myocardial strain peaks in the right ventricle of women were higher than those in men.(2)there was no significant gender difference in the global longitudinal strain and longitudinal diastolic strain rate.(3)The global radial strain,global circumferential strain,global circumferential strain for basal,global circumferential strain for mid,radial diastolic and systolic strain rate,circumferential diastolic strain rate correlation with age,along with the age growth increased in different degrees.(4)There was no significant correlation between right ventricular myocardial strain,strain rate and BMI.