The Regulation Of Basal Blood Glucose By Insulin Microneedles

Insulin is the treatment of all type I diabetes and part of the type II diabetes drugs,the main mode of administration for the control of postprandial blood glucose peak and basal blood glucose injection.Long-term injection to the patient has brought great inconvenience and pain,non-insulin administration of drugs will greatly improve the quality of life of patients.In the non-injection administration of insulin,the phase-transformed hydrogel microneedle technology of the present study group has the advantages of simple preparation,low cost,high safety and good performance of pharmacodynamics experiment,and has made breakthrough in the treatment of diabetes Sexual progress.But its role is equivalent to a premixed insulin drugs,mainly used to deal with postprandial blood glucose peaks and basal blood sugar between meals.The pharmacokinetic and pharmacokinetic studies of this formulation have demonstrated the advantages of being able to completely replace the injection and to facilitate portability and tolerance to temperature changes and to discontinue administration at any time when blood glucose is too low.In addition,for the type 2 diabetes,the group also developed a monthly needle exenatide long-acting sustained-release microspheres injection,the single-dose lower than the current US market,a weekly injection dose of single-dose,month Cumulative dose of products listed in the United States 1/5,and no peak plasma concentration,there is no common nausea,vomiting,diarrhea and other side effects.This ultra-long-acting preparations give full play to exenatide and other GLP-1 receptor agonists in the blood glucose response of the intelligent hypoglycemic effect.The two super drugs called the preparation of the existence of two shortcomings,respectively.For the insulin phase micro-needle patch,the production process than the conventional powder injection complex.The newly developed room temperature rapid 3D printing manufacturing technology greatly simplifies the future of the production process,the quality control part of the model does not have the right in vitro,it is difficult as the general injection as easy and fast.And exenatide per month a long-acting sustained-release microsphere preparations in type 2 diabetes patients in the slim in patients with poor control of basal blood glucose,so that the control of basal blood glucose still need a daily needle injection.The purpose of this study is to solve the above two problems.In the present study,we designed and fabricated an artificial dermal layer that can simulate the transdermal drug delivery dynamics of real animals(or humans),which is an accurate and rapid drug delivery system for microneedle transdermal delivery.Of the evaluation system.On this basis,for each month a needle exenatide long-acting sustained-release microsphere formulations still need some patients on a daily basis to add insulin injections unreasonable program,design and development of a daily basis of insulin transdermal Phase inversion microneedle patch.In the first study,we prepared polyvinyl alcohol(PVA)electrospun fiber membranes with hydrophilic,hydrated mechanical strength and good porosity to simulate the dermis.We optimized the PVA molecular weight,the number of freeze-thaw cycles after electrospray steam saturation,and the thickness of the electrospinning membrane.The kinetic curves of the blood concentration curves were simulated.Because microneedles as a new type of preparation,the tip can directly pierce the epidermis,contact with the dermis,the epidermis is no longer a micro-needle patch transdermal drug delivery process of the law steps to simulate the release of dermal layer kinetics become far more conventional The epidermal modeling in transdermal drug delivery studies is important.This result provides an extremely versatile tool for rapid evaluation of microneedle transdermal formulations.In the second study,we adjusted the density of microcrystalline domains,the type and dissolution rate of insulin and the microneedle formation of microcapsules formed by freeze-thawing of PVA on the basis of postprandial blood glucose control microneedle patch,The long-acting transdermal drug delivery was achieved on the artificial dermal layer model,and the effectiveness of the artificial dermis layer was verified.At present,the preparation of this model of pig pharmacokinetics experiments are ongoing.The invention in this study in the scientific principles and technical solutions to solve the diabetes drug therapy in two real problems,its further development will produce two expected to enter the practical application of new products.In addition,the mathematical model of the three-dimensional diffusion of macromolecules in the polymer matrix can be used as an important reference and theoretical support for studying the diffusion kinetics of other drugs in phase inversion microneedles.