Investigation On DC-CIK Cell Immunotherapy For Gastric Cancer

Background: Gastric cancer(GC)is the most common malignant tumor in the world with the fifth incidence and the second morbidity.However,the 5-year survival rate of patients with advanced gastric cancer is only 20%,so it is necessary to find a newly safer and more effective treatment.OBJECTIVE: To study the therapeutic effect and clinical significance of DC-CIK(dendritic cell-cytokine-induced killer cells)combined with chemotherapy on gastric cancer.METHODS: A total of 60 patients with primary gastric cancer admitted to the Second Hospital of Lanzhou University from Nov-2017 to Mar-2018 were randomly divided into two groups(control group and experimental group).The control group received chemotherapy alone after surgery,and the experimental group received che motherapy with DC-CIK cell immunotherapy which get registered at the Chinese Trial Registry.We compared the tumor marker levels(CA199,CEA),immune function(DC,CIK)of the patients at 4 weeks and 12 weeks after surgery,and 1-year Karnofsky(KPS)score,overall survival rate(OS)and recurrence rate(RR)between the two groups.RESULTS: the experimental get the lower level of the CA199 down 41.1% and CEA down 31.4% with a significant difference comparing with the control group at 12 weeks after surgery.(P<0.05).There were no significant differences in the level of tumor markers between after 4 weeks and 12 weeks in CA199 and CEA(P>0.05).But the number of the DC and CIK in the experimental group got more 130% and 28.6% than the control group(P<0.05).After 1 year of follow-up,the KPS scores of the experimental group were getting higher with functional status up 33.8% and physical condition up 47.9% comparing with control group,and the differences were statistically obvious(P<0.05).there was no significant difference in the OS and RR between the two groups(P>0.05).Conclusion: Postoperative chemotherapy combined with DC-CIK in gastric cancer has safe and effective clinical results.DC-CIK cell immunotherapy play a special role in preventing the cancer metastasis and deterioration,improving the quality of life of patients,and can improve the patient’s own immune function,enhance the immune system,reduce postoperative complications,and prolong their disease-free survival.