Study On The Characteristics Of TCM Constitutional Types And Their Relationship With Physical And Chemical Indicators In Patients With Chronic Hepatitis B In Southern Fujian

Objective The aim of this study is to analyze the characteristics of TCM constitutional types and their relationship with physical and chemical indicators in patients with chronic hepatitis B in southern Fujian,and to futher provide a reference for the prevention and treatment of chronic hepatitis B.Methods A total of 300 chronic hepatitis B patients proven by liver biopsy in southern Fujian were recruited in this study.All patients underwent questionnaire survey of TCM constitutional types and the results were analyzed along with general data and physical and chemical indicators.Results(1)Among 300 CHB patients,there were 249 cases with single TCM constitutional type and 51 cases with varied TCM constitutional types.The main biased TCM constitutional type were dampness-heat quality,and followed by qi-stagnation quality and yin-deficiency quality.(2)There was statistical significance in the age and gender distribution in CHB patients with different TCM constitutional types : The proportion of men was higher in patients with dampness-heat quality and gentleness quality,and the higher proportion of females was observed in patients with qi-deficiency or qi-stagnation quality.The age of patients who were classified as dampness-heat quality,qi-stagnation quality and gentleness quality mainly ranged from 18 to 30;and the age of patients with qi-deficiency quality,yang-deficiency quality,yin-deficiency,phlegm-dampness quality and blood-stasis quality were mainly in the 31-65 range.(3)There was statistical significance in the levels of ALT and AST in CHB patients with different TCM constitutional types: patients with dampness-heat quality had significantly elevated of ALT levels(?5×ULN),and nomal to minimally elevated ALT(?2×ULN)levels were observed in patients with qi-deficiency,yang-deficiency quality and gentleness quality.In accordance with ALT levels,patients with dampness-heat quality had higher AST levels,and the levels of AST in patients with qi-deficiency,yang-deficiency quality and gentleness quality were lower.(4)There was statistical significance in the HBeAg positive proportion in CHB patients with different TCM constitutional types: patients with dampness-heat and gentleness quality were more likely to be HBeAg positive CHB patients.(5)There was statistical significance in the grade of inflammation and necrosis of liver histological in CHB patients with different TCM constitutional types: most of patients with blood-stasis quality,qi-stagnation quality,yin-deficiency quality and dampness-heat quality were frequently noted as G?2.The stages of hepatic fibrosis in patients with blood-stasis quality and yin-deficiency quality were mainly manifested as S?2,which in patients with gentleness quality were demonstrated with S?2.Conclusions These data indicated that damp-heat quality,qi-stagnation quality and yin-deficiency quality were the main single TCM constitutional types in CHB patients in southern Fujian,and there were signicant differences in general data and physical and chemical indicators in CHB patients with different TCM constitutional types.The present study demonstrated that the acquaintance with the TCM constitution in CHB patients in southern Fujian would be of great significance to the prevention and treatment of CHB.