Clinical Study Of Huanglianejiao Decoction And Suanzaoren Decoction In Treating Insomnia By Yinxuhuowang

Objective:In clinical practice,the author found that Huanglian Ejiao Decoction and Suanzaoren Decoction had a significant effect on insomnia caused by Yin deficiency and fire exuberance.Through the comparative analysis of clinical cases,the author discussed the curative effect of Huanglian Ejiao Decoction and Suanzaoren Decoction on insomnia caused by Yin deficiency and fire exuberance compared with that of single treatment,and explored a better method for clinical treatment of insomnia.Methods:According to the diagnostic criteria of Western medicine,TCM diagnosis criteria and TCM syndrome classification criteria,114 insomnia patients who met the criteria of Yin-deficiency and Fire-exuberance were randomly collected from Quanzhou First Hospital Affiliated to Fujian Medical University during the period of Jan1,2017-May31,2018.in Huanglian Ejiao Decoction group(37 cases),Suanzaoren Decoction group(36 cases)and combined treatment group(35 cases).The combined treatment group was treated with Huanglian Ejiao Decoction and Suanzaoren Decoction: roasted licorice 3g,Poria Cocos 18 g,Anemarrhena asphodeloides 6g,Chuanxiong 6g,fried jujube seed 18 g,Scutellaria baicalensis 3g,Coptis chinensis 3g,Ejiao 10 g,raw peony 18 g.Huanglian Ejiao Decoction group was treated with Huanglian Ejiao decoction,Huangqin 3g,Coptis 3g,donkey hide gelatin 10 g and Sheng Shao 18 g.Suanzaoren Decoction was simply given Suanzaoren Decoction,Licorice 3g,Poria cocos 18 g,Rhizoma Anemarrhenae 6g,Ligusticum chuanxiong 6g and stir fried semen Zizyphi jujube kernel 18 g.Pittsburgh sleep quality index(PSQI)evaluation,neurotransmitter 5-hydroxytryptamine(5-HT),Dopamine(DA)and Norepinephrine(NE)were measured before and after 30 day's treatment.Patients were asked about their medication every week after treatment,and those who did not follow the prescription should make corresponding explanations.Results:1.There was no statistically significant difference in age,sex,illness and duration between the three groups(P>0.05).2.In the overall efficacy comparison:The total effective rate of the three groups(complete healing + significantly effective + effective)was not statistically significant(P > 0.05).There was significant difference in the marked efficiency between the combined treatment group,Huanglian Ejiao Decoction group and Suanzaoren Decoction group(complete healing + significantly effective)(P < 0.05).It shows that all three groups can treat insomnia of Yin deficiency and fire exuberance,and the combined treatment group is more effective than the other two groups.3.From the PSQI reduction rateThe total effective rate of the three groups(complete healing + significantly effective + effective)was not statistically significant(P > 0.05).There was significant difference in the marked efficiency between the combined treatment group,Huanglian Ejiao Decoction group and Suanzaoren Decoction group(complete healing + significantly effective)(P < 0.05).It shows that all three groups can treat insomnia of Yin deficiency and fire exuberance,and the combined treatment group is more effective than the other two groups.4.NeurofactorThere was significant difference between the three groups before and after treatment(P<0.05).The levels of 5-HT in plasma of the three groups were increased,and the increase in the combined treatment group was more significant(P < 0.05).The levels of DA and NE in plasma of the three groups decreased before and after treatment,and the decrease in the combined treatment group was more significant(P < 0.05).It indicates that the three groups can treat insomnia due to yin deficiency and fire type,and the curative effect of combined treatment group is higher than that of the other two groups.5.Adverse reactionsThere were no abnormal changes in routine hematuria,liver and kidney function,electrocardiogram and basic vital signs before and after treatment.Conclusion:Through the collection and analysis of clinical cases,we can know that all three groups can improve the sleeping condition of insomnia patients with Yin deficiency and fire prosperity.Huanglian Ejiao Decoction and Suanzaoren Decoction are better than single treatment in treating insomnia caused by Yin deficiency and fire prosperity.It can improve clinical efficacy and relieve the clinical symptoms of patients.