Meta Analysis Of The Effect Of Verapamil In The Treatment Of Patients With STEMI Without Reflow During Emergency PCI Operration

Objective: The clinical efficacy of verapamil in the treatment of acute ST-segment elevation myocardial infarction(STEMI)patients without reflow during emergency PIC was evaluated by systematic evaluation.Methods:Search for RCTs in Chinese and English databases of Wanfang,ChinaNet,Weip,China Biomedical Database,PubMedMedCochrane Library Science,New England Journal,etc,by Computer.The retrieval time was up to October 2016.The literature was independently screened by two researchers according to inclusion and exclusion criteria.At the same time,the standard of partial oddity risk provided by Cochrane cooperation network is used to evaluate the quality of the included literature,and the data are statistically analyzed by using RevMan 5.3 software.Results:The study included 7 randomized controlled trials.A total of 890 patients.Meta-analysis results showed that: compared with the control group given tirofiban,nitroglycerin,heparin group,The incidence of no reflow,adverse cardiovascular events,early St segment descent > 50% and cardiac function improvement in patients with STEMI during P-PCI were significantly higher than that in the group treated with verapamil via suction catheter.There was a significant difference in the improvement of cardiac function between the two groups(P < 0.05).Conclusion:Administration of verapamil to the distal end of the target lesion via suction catheter could significantly improve the blood flow perfusion of the target vessel and myocardial tissue perfusion,decrease the elevation of St segment in a short period of time,and reduce the occurrence of adverse cardiovascular events.It is an effective method to treat the phenomenon of no resuscitation or slow reflow.